【摘要】 α-氨基酰胺作为一类重要的羰基化合物广泛存在于众多天然的和非天然的生物活性分子之中.本工作实现了芳胺NH对在水相体系中通过金催化的分子间氧化炔烃途径产生的α-羰基金卡宾的插入反应.这种通过非重氮方式产生α-羰基金属卡宾的策略为有效合成多种官能团化的α-氨基酰胺化合物提供了一种通用且实用的方法.更多还原

【Abstract】 α-Amino amides constitute an important category of carbonyl compounds which exist in a large number of bioactive natural and non natural molecules. In this paper, an efficient intermolecular reaction of gold carbene intermediates, generated through gold-catalyzed intermolecular oxidation of alkynes, with primary anilines has been realized in aqueous media. Importantly, this non-diazo approach provides a general and practical solution for the synthesis of various functionalized α-amino amides.更多还原