【摘要】 Mitsunobu反应是醇与酸性化合物偶联形成新化学键的一种有效方法,可以用来构建碳-氧、碳-氮、碳-硫及碳-碳等化学键,在天然产物和功能有机分子的合成中已得到了非常广泛的应用.对Mitsunobu反应的机理及其在构建化学键中的应用进行了介绍,并对该反应的区域选择性进行了较为系统的总结.更多还原

【Abstract】 The Mitsunobu reaction is an effective method for making a new chemical bond by condensation of an alcohol with an acidic compound. It can be applied for the construction of C—O, C—N, C—S and C—C bonds, and has been widely used in the synthesis of natural products and functional organic molecules. In this review, the mechanism of the Mitsunobu reaction and its application in the construction of chemical bonds are introduced. Moreover, the regioselectivity of this reaction is systematically summarized.更多还原