【摘要】 目的观察负荷量阿托伐他汀对不稳定性心绞痛患者经皮冠状动脉介入(PCI)术后心肌的保护作用。方法不稳定性心绞痛患者178例随机分为A组(术前24h内给予负荷量阿托伐他汀80mg,90例)和B组(术前不用阿托伐他汀,88例),两组PCI术后均予阿托伐他汀20mg/d。检测术前和术后24h炎症因子及心肌损伤标记物水平。结果 A组术后各项相关指标均较术前略有升高(P>0.05)。B组术后超敏C反应蛋白、髓过氧化物酶、TNF-α、IL-1、IL-6、心肌肌钙蛋白I、肌酸磷酸激酶同工酶均高于术前和A组(P<0.05)。结论不稳定性心绞痛患者PCI术前予阿托伐他汀负荷剂量预治疗可减少炎症反应,保护心肌功能。更多还原

【Abstract】 Objective To observe the protective effects of preoperative loading dose atorvastatin on the myocardium of the patients with unstable angina undergoing pereutaneous coronary intervention(PCI).Methods A total of 178 patients with unstable angina was randomly assigned into two groups of A(injection of atorvastatin 80 mg before PCI,90cases)and B(without preoperative injection of atorvastatin,88cases).Atorvastatin 20mg/d was given after PCI in two groups.The levels of inflammatory factors and the markers related to myocardial injury were detected before and at 24 hour after PCI.Results There were no significanct differences in all indicators measured between before and at 24 hour after PCI in group A.The levels of high sensitive C-reactive protein,myeloperoxidase,TNF-α,IL-1,IL-6,cardiac troponin I and creatine kinase-MB after PCI in group B were all higher than those before PCI and in group A(P<0.05).Conclusion Loading dose atorvastatin given before PCI in patients with unstable angina can reduce inflammatory responses and protect myocardial function.更多还原