【摘要】 目的研究铁调素和膜转铁蛋白(FPN)在胃癌组织中的表达及其临床意义。方法应用免疫组化染色法检测62例胃癌组织和15例癌旁正常胃黏膜组织中铁调素和FPN的蛋白表达,分析其与临床病理特征的关系。结果与癌旁正常胃黏膜组织相比,胃癌组织中铁调素阳性表达率增加(56.5%vs.20.0%)(P<0.05),而FPN阳性表达率减少(54.8%vs.80.0%)(P<0.05)。铁调素和FPN表达均与TNM分期有关(P<0.05),而与年龄、性别、淋巴结转移、远处转移及贫血无关(P>0.05)。铁调素与FPN表达呈负相关(r=-0.27,P<0.05)。结论胃癌组织高表达铁调素、低表达FPN,联合检测铁调素和FPN可以作为反映胃癌生物学行为的客观指标。更多还原

【Abstract】 Objective To investigate the expressions and clinical significance of hepcidin and ferroportin(FPN)in gastric cancer.Methods The expressions of hepcidin and FPN were detected by immunohistochemistry assay in gastric cancer(62 cases)and tumor-adjacent normal tissues(15 cases).The correlation between the expressions and clinicopathologic characteristics was analyzed.Results Compared with tumor-adjacent normal tissues,the positive expression rate of hepcidin in the tissues of gastric cancer was increased(56.5% vs.20.0%)(P<0.05),while that of FPN was decreased(54.8%vs.80.0%)(P<0.05).Both expressions of hepcidin and FPN were correlated with TNM staging(P<0.05),but were not relevant to age,sex,lymph node metastasis,distant metastasis and anemia(P>0.05).The expression of hepcidin was negatively correlated with that of FPN(r=-0.27,P<0.05).Conclusion Hepcidin is highly expressed,while FPN is lowly expressed in gastric cancer.Combined detection of hepcidin and FPN can objectively reflect the biological behavior of gastric cancer.更多还原