【摘要】 目的探讨进展期胃癌组织中乳腺癌易感基因1(BRCA1)的表达及其与预后的关系。方法采用免疫组化方法检测637例进展期胃癌组织中BRCA1蛋白的表达,并分析患者预后情况。结果 219例(34.4%)胃癌组织中BRCA1蛋白表达阳性。BRCA1蛋白的表达与肿瘤分化程度相关(P<0.01)。单因素分析显示,BRCA1阳性表达患者生存时间长于阴性表达者(P<0.05);多因素分析显示,肿块大小、浸润深度、区域淋巴结转移、脉管神经侵犯及有无化疗是影响胃癌根治术后患者生存的独立预后因素(P<0.05)。结论 BRCA1阳性表达的胃癌患者预后较好,但BRCA1并非影响术后生存的独立预后因素。更多还原

【Abstract】 Objective To study the expression of breast cancer susceptbility gene 1(BRCA1)in gastric cancer tissues of patients with advanced gastric cancer and its relationship with the prognosis.Methods The expression of BRCA1 protein in advanced gastric cancer tissues of 637 cases was evaluated by immunohistochemistry.The relationship between BRCA1 expression and prognosis of patients was analyzed.Results The positive expression of BRCA1 protein was found in 219cases(34.4%).The expression of BRCA1 protein was related to the degree of tumor differentiation(P<0.01).Univariate analysis showed that survival time of the patients with positive expression of BRCA1 was longer than that of those with negative expression(P<0.05).Multivariate analysis showed that tumor size,infiltration depth,regional lymph node metastasis,vascular invasion and presence of chemotherapy were the independent prognostic factors(P<0.05).Conclusion Gastric cancer patients with positive expression of BRCA1 have a good prognosis,while BRCA1 is not an independent prognostic factor of postoperative survival.更多还原