【摘要】 目的探讨Nav1.6在口腔鳞状细胞癌组织中的表达,以及Nav1.6在口腔鳞状细胞癌发生中的相关性。方法采用免疫组化SP法、荧光定量PCR法,对50例口腔鳞癌组织及16例非癌症组织中Nav1.6表达进行检测,利用仪器对结果进行分析。结果口腔鳞癌组织中Nav1.6的表达量高于非癌症组织。随着分化程度的增高,Nav1.6的表达量逐渐减少。其表达量与患者年龄、性别、肿瘤部位、有无淋巴结转移无关。结论 Nav1.6的上调可能与口腔鳞癌的生物学行为有关,其作用机制有待进一步研究。更多还原

【Abstract】 Objective To investigate the expression of Nav1. 6 in oral squamous cell carcinoma and the relationship between Nav1. 6 and the development of oral squamous cell carcinoma. Methods Immunohistochemistry,real-time quantitative PCR were used to detect the expression of Nav1. 6 in carcinoma and normal human oral tissue. The the results were analyzed by using instruments. Results The results revealed that the expression of Nav1. 6 in oral squamous cell carcinoma increased significantly in comparison with the normal oral tissue. The higher the degree of tumor differentiation,the less the expression of Nav1. 6. And the expression of Nav1. 6 had nothing to do with age,sex,the site of tumor and the metastasis of lymph nodes. Conclusion The up-regulated level of Nav1. 6 mRNA in oral squamous cell carcinoma tissue is significantly associated with the pathogenesis of OSCC.更多还原