【摘要】 目的观察两色金鸡菊乙酸乙酯提取物对糖尿病大鼠糖脂代谢及肝脏、肾脏功能的影响。方法高糖高脂喂养联合腹腔注射链脲佐菌素(streptozotocin,STZ)建立2型糖尿病SD大鼠模型,成模大鼠随机分6组(正常组、模型组、两色金鸡菊乙酸乙酯提取物高、中、低3个剂量组0.15、0.3、0.6 g·kg-1、阳性药二甲双胍0.16 g·kg-1组)。正常组和模型组灌胃生理盐水,其余组每天灌胃给药两色金鸡菊提取物,每周测体重及随机血糖,给药4周后处死,收集大鼠血清,检测血脂四项、肝功肾功指标、血清胰岛素及糖化血红蛋白水平。结果两色金鸡菊乙酸乙酯提取物可有效降低糖尿病大鼠的随机血糖和糖化血红蛋白及血清甘油三酯、低密度脂蛋白、血清总蛋白、血肌酐及血尿酸水平,同时能升高糖尿病大鼠血清白蛋白的含量。结论两色金鸡菊乙酸乙酯提取物能降低糖尿病SD大鼠的血糖血脂,保护其肝肾功能。更多还原

【Abstract】 Aim To observe the effects of the ethyl ace-tate extract from Coreopsis tinctoria on glucose and lipidmetabolism and liver,kidney function in diabetic rats.Method By high-sugar,high-fat diet combined with intraperitoneal injection of streptozotocin( streptozotocin,STZ) Type 2 diabetes SD rat model was established.Model rats were randomly divided into six groups( control group,model group,three dose groups Coreopsis tinctoria extract:low,middle,high 0.15 g·kg-1; 0.3 g·kg-1; 0.6 g·kg-1,positive drug metformin 0.16 g · kg-1group).The control group and the model group were given physiological saline and the remaining groups intragastric administration coreofosis tinctoria extrat.Random blood glucose and body weight of rats were measured weekly.After 4 weeks of administration,The rats were killed and rat serum was col-lected to detect serum lipids( TC/TG/HDL/LDL),liver and renal function indicators,serum insulin,and glycated hemoglobin levels.Result Coreopsis tinctoria ethyl acetate extract effectively reduced the diabetic rats random blood glucose,glycated hemoglobin,serum triglycerides,LDL,total serum protein,serum creatinine and uric acid levels,and increased serum white protein content in diabetic rats.Conclusion Coreopsis tinctoria ethyl acetate extract can reduce blood glucose and lipid in diabetic SD rats and protect their liver and kidney function.更多还原