【摘要】 目的 研究右美托咪定联合盐酸羟考酮对食管癌手术患者麻醉苏醒期躁动的影响。方法 入选食管癌手术患者50例，随机分为盐酸羟考酮组（A组）、右美托咪定联合盐酸羟考酮组（B组）,术后采用患者自控镇痛（PCA）,并记录麻醉诱导前（T₁）及拔管后1 h（T₂）、6 h（T₃）、12 h（T₄）、24 h（T₅）时的收缩压（SBP）、舒张压（DBP）、心率（HR）、脉搏氧饱和度（SpO₂）及各组的术后躁动发生率、Ramsay评分及疼痛视觉模拟评分（VAS）情况。结果 2组患者一般情况无明显差异（P>0.05）;和A组比较，B组患者Ramsay评分增高（P<0.05）,VAS评分和躁动发生率减低（P<0.05）。结论 右美托咪定联合盐酸羟考酮用于开胸食管癌术后镇痛可使患者苏醒期安静合作，明显减少麻醉苏醒期躁动发生率。更多还原

【Abstract】 Objective To investigate the effects of oxycodone hydrochloride and dexmedetomidine on emergence agitation of patients with esophageal cancer after anesthesia. Methods Fifty ASA grade I-II patients undergoing esophageal cancer operation were randomly divided into two groups: an oxycodone hydrochloride group（group A） and a dexmedetomidine and oxycodone hydrochloride group（group B）, with 25 patients in each group. After surgery, patient-controlled analgesia was provided. The systolic blood pressure（SBP）, diastolic blood pressure（DBP）, heart rate（HR）, blood oxygen saturation（SpO₂）, the incidence of agitation, VAS score and Ramsay sedation score were recorded at the following time points: before induction of anesthesia（T₁）, 1 hour after operation（T₂）, 6 hours after operation（T₃） 12 hours after operation（T₄）, and 24 hours after operation（T₅）. Results There was no significant difference between the two groups in their general condition（P>0.05）. Compared with Group B, patients in Group A produced higher Ramsay scores, VAS scores and lower agitation rates（P<0.05）. Conclusion Oxycodone hydrochloride combined with dexmedetomidine can significantly reduce the incidence of emergence agitation, which can be applied for postoperative analgesia for esophageal cancer patients after operation.更多还原