【摘要】 目的探讨ox-LDL检测在2型糖尿病肾病患者中的价值。方法将90例糖尿病肾病患者分为正常蛋白尿组、微量蛋白尿组和大量蛋白尿组。另选取20例健康者作为正常对照组。检测血ox-LDL浓度、尿微量白蛋白、尿8-OHd G、N-乙酰?β?氨基葡萄糖苷酶(NAG)等指标。结果糖尿病组血ox-LDL水平显著高于正常对照组(P<0.01);大量蛋白尿组的血oxLDL水平明显高于微量蛋白尿组及正常蛋白尿组(P<0.01)。糖尿病肾病患者血ox-LDL水平与总胆固醇、低密度脂蛋白、甘油三酯及脉压差呈正相关,与BMI及HDL-C呈负相关。ox-LDL水平与尿微量白蛋白、尿8-OHd G、NAG、α2-MG、FDP呈显著正相关。结论糖尿病肾病患者随着蛋白尿的增多其脂质的氧化应激水平增强,且脂质氧化应激作为重要因素参与糖尿病肾病的发生与发展。更多还原

【Abstract】 Objective To investigate the value of serum ox-LDL detection in patients with diabetic nephropathy( DN). Methods A total of 90 DN patients were divided into normal proteinuria group,micro proteinuria group and large amount proteinuria group. Twenty healthy people were selected as control group. The indicators of serum ox-LDL concentration,microalbuminuria,urinary 8-OHd G and NAG were measured. Results The level of serum ox-LDL in DN patients were significantly higher than that of the control group( P<0. 01). The level of ox-LDL in the large amount proteinuria group was significantly higher than that of normal proteinuria group and micro proteinuria group( P<0. 01). The level of serum ox-LDL was positively correlated with total cho1 esterol,triglyceride and low-density 1ipoprotein as well as pulse pressure,but was negatively correlated with BMI and HDL-C. The level of serum ox-LDL was positively correlated with the urinary albumin and urine8-OHd G,NAG,α2-MG and FDP. Conclusion The lipid oxidative stress increases significantly with the enhancement of proteinuria in DN patients,and it is correlated with the development and progression of DN.更多还原