【摘要】 目的观察胸腺五肽对尖锐湿疣患者Th1/Th2平衡和疗效的影响。方法 84例尖锐湿疣患者随机分为对照组和治疗组,每组42例。另选取健康体检者30例作为正常对照组。所有尖锐湿疣患者均采用二氧化碳激光局部电灼术,对照组加用膦甲酸钠40 mg·kg-1,每日2次,疗程15 d;治疗组加用胸腺五肽2 mg,每日1次,疗程3周。治疗前和治疗后3个月采用ELISA法检测患者血清干扰素γ(IFN-γ)、白细胞介素2(IL-2)、IL-4、IL-10的浓度,治疗后6个月评价临床疗效。结果与正常对照组相比,尖锐湿疣患者的血清IFN-γ、IL-2水平降低,IL-4、IL-10水平升高(P<0.01)。治疗前对照组和治疗组患者血清IFN-γ、IL-2、IL-4、IL-10水平无明显差异(P>0.05)。对照组完成41例,治疗后血清IFN-γ、IL-2、IL-4、IL-10水平无明显变化(P>0.05)。治疗组完成39例,治疗后血清IFN-γ、IL-2水平升高,IL-4、IL-10水平降低(P<0.05或P<0.01)。治疗组治疗后血清IFN-γ、IL-2水平明显高于对照组,而IL-4、IL-10明显低于对照组(P<0.05或P<0.01)。治疗组的复发率亦低于对照组(15%vs.37%,P<0.05)。两组患者均未出现严重不良反应。结论胸腺五肽可能通过调节Th1/Th2平衡及增强细胞免疫功能,从而对尖锐湿疣起到治疗作用。更多还原

【Abstract】 AIM To observe the effects of thymopetidum on Th1/Th2 balance and efficacy in patients with condyloma acuminatum(CA). METHODS Eighty- four patients with CA were randomly devided into two groups( control group and therapy group, each 42 patients). In addition, 30 healthy age-, gender-, body mass index- matched healthy subjects were selected as normal group. The patients in the control group were treated with local fulguration and foscarnet sodium( 40 mg·kg-1, bid, for 15 days), whereas patients in the therapy group were treated with thymopetidum( 2 mg, qd, for 3 weeks) besides local fulguration. The serum concentration of interferon- γ(IFN- γ), interleukin- 2(IL- 2), interleukin- 4(IL- 4), interleukin- 10(IL-10) were assayed with enzyme linked immunosorbent assay(ELISA) before therapy and 3 months after therapy.The clinical efficacy was assessed 6 months after therapy. RESULTS Compared with the normal group, the serum concentrations of IFN- γ and IL- 2 were significantly lower in the CA patients, whereas the serum IL- 4and IL- 10 levels were significantly higher(P < 0.01). There were no significant differences of serum IFN- γ,IL- 2, IL- 4 and IL- 10 levels between the control group and therapy group before the treatment( P > 0.05).There were 41 patients completed the trial in the control group, and no significant changes of serum IFN- γ, IL-2, IL- 4 and IL- 10 levels were found after the treatment(P > 0.05). Thirty- nine patients completed the trial in the therapy group, and the IFN- γ and IL- 2 levels increased significantly after the treatment, whereas the IL- 4and IL- 10 levels decreased significantly(P < 0.05 or P < 0.01). Compared with the control group, the IFN- γand IL- 2 levels in the therapy group were higher, whereas the IL- 4 and IL- 10 levels were lower(P < 0.05 or P < 0.01). The recurrence rate in the therapy group was significantly lower than that in the control group(15%vs. 37%, P < 0.05). No serious adverse reactions occurred in both groups. CONCLUSION Thymopetidum maybe create the significant therapeutic action on patients with CA by regulating Th1/Th2 balance and enhancing cellular immune function.更多还原