【摘要】 目的观察高脂饲料喂养14周的长爪沙鼠生化指标变化。方法选取雄性长爪沙鼠20只,随机分为高脂饲料组和对照组,每组10只。对照组喂养普通饲料,高脂饲料组喂养含1.0%胆固醇、20.0%猪油的高脂饲料。14周后颌下静脉丛采血,检测血糖(GLU)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)等。结果高脂饲料组长爪沙鼠血清TC、LDL-C、TG、HDL-C水平[分别为(14.27±2.97)、(4.72±1.94)、(3.04±1.22)、(3.43±0.90)mmol/L]明显高于对照组[分别为(1.72±0.22)、(0.19±0.09)、(1.53±0.49)、(1.46±0.25)mmol/L],差异均有统计学意义(P<0.01)。GLU水平[(6.47±0.55)mmol/L]低于对照组[(8.19±1.02)mmol/L],但差异无统计学意义(P>0.05)。结论高脂饲料喂养能明显升高长爪沙鼠血脂水平,导致长爪沙鼠高脂血症。更多还原

【Abstract】 Objective To observe the change of serum biochemical indicators in Mongolian gerbils fed by 14-week highfat diet. Methods 20 male Mongolian gerbils were selected and randomly divided into the high-fat fodder group and the control group,10 cases in each group. The control group was fed with common fodder,while the high-fat fodder group was given the highfat fodder containing 1.0% cholesterol and 20.0% lard. The venous blood was collected by submaxillary venous plexus after 14 weeks. The serum GLU,TG,TC,HDL-C and LDL-C,etc. were detected. Results The levels of serum TC,LDL-C,TG and HDLC in the high-fat fodder group were(14.27±2.97),(4.72±1.94),(3.04±1.22),(3.43±0.90)mmol/L respectively,which were significantly higher than(1.72±0.22),(0.19±0.09),(1.53±0.49),(1.46±0.25) mmol/L in the control group respectively,the differences were statistically significant(P<0.01),but the GLU level was lower than that in the control group without statistical difference[(6.47±0.55)mmol/L vs.(8.19±1.02)mmol/L,P>0.05]. Conclusion The high-fat fodder feeding can significantly increase serum lipid level in Mongolian gerbils and induces its hyperlipidemia.更多还原