【摘要】 目的观察帕金森病(PD)合并抑郁患者应用艾司西酞普兰治疗的临床效果。方法选取2012年9月至2014年12月在该院就诊的PD合并抑郁患者102例,采用随机数字表法分为对照组(采用西酞普兰治疗)和观察组(采用艾司西酞普兰治疗),各51例,对比2种药物的疗效。结果经治疗后,两组患者的汉密尔顿抑郁量表、汉密尔顿焦虑量表、帕金森统一评分量表评分均显著低于治疗前,且观察组明显优于对照组,总有效率[92.16%(47/51)]也显著高于对照组[76.47%(39/51)],差异均有统计学意义(P<0.05)。结论采用艾司西酞普兰治疗PD合并抑郁效果明显,值得推广应用。更多还原

【Abstract】 Objective To observe the clinical effect of escitalopram in treating Parkinson ′s disease(PD) complicating depression. Methods 102 patients with PD complicating depression in our hospital from September 2012 to December 2014 were selected and divided into the control group treated by citalopram and observation group treated by escitalopram according to the random number table method,51 cases in each group. The therapeutic effects were compared between the two kinds of drug.Results The HAMD,HAMA and UPDS scores after treatment in the two groups were significantly lower than those before treatment,moreover which in the observation group were significantly superior to the reference group(P<0.05);the total effective rate in the observation group was 92.16%(47/51),which was significantly higher than 76.47%(39/51) in the control group,the difference was statistically significant(P<0.05). Conclusion Using escitalopram has obvious effect in treating PD complicating depression and is worth promoting and applying.更多还原