【摘要】 目的:探讨骨髓涂片与骨髓活检同步分析在多发性骨髓瘤诊断中的意义。方法:对我院2014年30例多发性骨髓瘤患者进行骨髓穿刺抽吸,同步进行骨髓活检取材,分析骨髓涂片及同步骨髓活检结果。结果:骨髓活组织切片中骨髓增生程度明显高于骨髓涂片,均为活跃及活跃以上,可观察到灶状及弥漫状分布骨髓瘤细胞;30例患者中22例(73%)可见双核、多核浆细胞,骨髓涂片中病态浆细胞的检出率为40%,差异具有统计学意义(P<0.05)。骨髓活检Gomori染色可见不同程度的骨髓纤维组织增生,以轻、中度增生为主,骨髓纤维组织增生程度与浆细胞比例存在一定程度正相关性(r=0.412)。结论:骨髓涂片联合骨髓活检可相互取长补短,减少漏诊率,有利于MM患者的早期诊断和治疗。更多还原

【Abstract】 Objective:To explore the value of bone marrowsmear and biopsy simultaneously applied to diagnosis of multiple myloma(MM).Methods:Clinical data of 30 cases of multiple myloma were collected from our hospital in the year 2014 and analyzed retrospectively,and the results of the bone marrowsmear and the simultaneous bone marrowbiopsy were compared.Results:Hyperplasia levels in bone marrowbiopsy was significantly higher than that in bone marrowsmears,and the active and highly active hyperplasia of nucleated cells were observed in all the bone marrowbiopsies;the myeloma cells showed a focal or diffuse distribution,the binuclear or polynuclear myeloma cells were observed in 22 patients(73%),but the detection rate of abnormal myeloma cells was 40%in bone marrowsmear(P <0.05).There was mild to moderate hyperplasia of fibrous tissue in bone marrowbiopsy,and the hyperplasia degeree of fibrous tissue strongly positively correlated with the myeloma cell ratio(r =0.412).Conclusion:The bone marrowsmear and aspiration biopsy can complement each other so as to reduce the misdiagnosis rate,therefore contributes to the early diaglosis and treatment.更多还原