【摘要】 嵌合抗原受体(chimeric antigen receptor,CAR)是一种合成跨膜蛋白,通过抗肿瘤细胞上的特异性或相关性抗原来重新定向被修饰的细胞。CAR修饰的T/NK细胞,特别是CAR-T细胞是近年来迅速发展的肿瘤过继免疫治疗新手段,它赋予T/NK细胞靶向杀伤活性,并可克服肿瘤局部免疫抑制微环境和打破宿主免疫耐受状态。CAR将识别肿瘤相关抗原的单链抗体和T/NK细胞的活化基序相结合,通过基因转导赋予T/NK细胞肿瘤靶向性、更强的杀伤活性和持久的生命力。本文就CAR发展、CAR-T和CAR-NK细胞的比较、MM细胞的表面标记和CAR在MM中的应用及CAR-T/NK细胞的前景进行综述。更多还原

【Abstract】 Chimeric antigen receptor(CAR) is a synthesized transmembrane protein,which redirects the modified cells through specific or associated antigen on tumor cells.CAR-modified T/NK cells,especially CAR-T cells,are a new tool of rapidly developing of adoptive immunotherapy of tumor in recent years,they give T/NK cells the targeting cytotoxic activity and can overcome the tumor immunosuppressive microenvironment and break the state of the host immune tolerance.CAR combines the single-chain antibody to tumor-associated antigen with T/NK cells’ activated motifs,giving T/NK cells’ tumor targeting activity,so enhancing their cytotoxic activity and lasting the vitality by gene transduction.In this article the CAR development,comparison of CAR-T and CAR-NK cells,surface markers on MM cells and use of CAR in MM,and CAR perspectives are summarized.更多还原