【摘要】 目的研究宫颈癌及癌前病变相关危险因素。方法选取宫颈上皮内瘤样病变(CIN)及宫颈癌患者2 000例为研究对象,进行问卷调查;另选取同期接受健康检查育龄妇女病理证实无CIN病变者1 000例作为对照人群。结果 CINⅠ、CINⅡ、CINⅢ均集中在20~49岁,20~39岁最为集中;宫颈癌主要集中在30~49岁及≥50岁年龄段,以30~49岁构成比例最高。CINⅠ组、CINⅡ组和CINⅢ组在20~29、30~39岁构成比,两两比较差异有统计学意义(P<0.05),其余年龄段两两比较差异均无统计学意义(P>0.05);CINⅠ组、CINⅡ组和CINⅢ组与宫颈癌组在20~29、40~49、≥50岁构成比比较差异有统计学意义(P<0.05),其余年龄段两两比较差异均无统计学意义(P>0.05)。Logistic回归分析显示,人乳头状瘤病毒(HPV)感染、初次性生活年龄、户籍情况及性生活年限与宫颈癌及癌前病变的发生存在明显相关性(P<0.05)。结论宫颈癌及癌前病变相关危险因素主要有初次性生活年龄过小、HPV感染、性生活年限过长及非本地户口等。更多还原

【Abstract】 Objective To study the risk factors of cervical cancer and precancerous lesions. Methods A total of 2 000 patients with cervical intraepithelial neoplasia( CIN) or cervical cancer were enrolled in this study; at the same time,the1 000 reproductive life women who underwent physical examination and without CIN confirmed by pathology were selected as the control population. Results The CIN Ⅰ,CIN Ⅱ and CIN Ⅲ patients were mainly concentrated in the 20- 49 years old,and 20- 39 years old were the most. The cervical cancer patients were mainly concentrated in 30- 49 years old and ≥50 years old,and 30- 49 years old were the most. There was statistic difference of the constituent ratio of CIN Ⅰ,CIN Ⅱ and CIN Ⅲpatients number in 20- 29,30- 39 years among CIN Ⅰ group,CIN Ⅱ group and CIN Ⅲ group( P < 0. 05); there was no statistic difference at the other age among the three groups( P > 0. 05). There was statistic difference of the constituent ratio of CIN Ⅰ,CIN Ⅱ,CIN Ⅲ and cervical cancer patients number in 20- 29,40- 49,≥50 years between CIN Ⅰ group,CIN Ⅱgroup,CIN Ⅲ group and cervical cancer group( P < 0. 05); there was no statistic difference at the other age among the groups( P > 0. 05). The logistic regression analysis showed that the human papilloma virus( HPV) infection,the age of first sexual life,censue register and sex life were significantly correlated with cervical cancer and precancerous lesions( P < 0. 05). Conclusion The HPV infection,initial sexual age is too small,sexual life too long,non-local censue register etc,were the mainly risk factors of cervical cancer and precancerous lesions.更多还原