【摘要】 目的 探讨血清内脂素水平与颈动脉粥样硬化的关系。方法 根据颈动脉超声结果 将受试者分为无斑块组(638例)和斑块组(205例),均检测血压、身高、体重、腰围、臀围、体质指数;采用酶联免疫吸附法检测血清内脂素水平;放射免疫法检测血清肿瘤坏死因子-α。结果 ①斑块组血清内脂索水平及肿瘤坏死因子-α均高于无斑块组(P<0.01)。②Logistic回归分析显示,年龄、收缩压、低密度脂蛋白胆固醇、血清内脂素及肿瘤坏死因子-α均与颈动脉斑块独立相关(P<0.05)。③受试者工作特征曲线(ROC曲线)显示,血清内脂素对颈动脉斑块形成的诊断准确性为0.838(P<0.01)。结论 血清内脂素水平升高与颈动脉粥样硬化密切相关,并可作为颈动脉斑块形成的可靠评价指标。更多还原

【Abstract】 Objective To explore the relationship between serum visfatin level and carotid atherosclerosis.Methods Based on the results of carotid artery echocardiography,participants were divided into the group without carotid plaque(n=638) and group with carotid plaque(n=205).Blood pressure,body height,body weight,waist and hip circumference,body mass index(BMI) were measured.Serum visfatin concentration was assessed by enzyme immunoassay and TNF—a was measured using radioimmunity kits.Results(l)The serum visfatin concentration and TNF-a were significantly increased in the group with carotid plaque compared to group without carotid plaque(P<0.01).(2)Logistic regression indicated that age,systolic blood pressure,low density lipoprotein cholesterol,TNF-α and visfatin were all independently associated with the prevalence of carotid atherosclerosis(P<0.05).(3)Receiver operating characteristic curve(ROC) revealed that the diagnostic accuracy of visfatin for carotid atherosclerosis was 0.838(P<0.01).Conclusion Visfatin was significantly associated with carotid atherosclerosis and it was valuable to evaluate the formation of carotid plaque.更多还原