Schistosomiasis causes the imbalance of fibrogenesis and pro-fibrinolytic promoting factors,leading to extracellular matrix deposition and liver fibrosis. The activation of liver macrophages(Kupffer cells)and stellate cells are the two crucial events,which constitute a complex network regulating fibrosis balance. This review discusses the function of fibrotic cytokines secreted by macrophages,and their interaction and mutual influence with stellate cells in hepatic fibrosis. Additionally,the expected progre...