【摘要】 目的探讨利拉鲁肽联合盐酸二甲双胍治疗维吾尔族和汉族肥胖2型糖尿病(T2DM)的临床疗效。方法采用开放式随机对照研究的方法,按照序贯进入的原则,选择新疆医科大学第一附属医院住院的肥胖T2DM患者132例,其中利拉鲁肽+盐酸二甲双胍组66例(维吾尔族21例,汉族45例),盐酸二甲双胍组66例(维吾尔族29例,汉族37例)。比较两组患者治疗前及治疗后3、6个月体质指数(BMI)、糖化血红蛋白(HBA1c)、腰臀比(WHR)、空腹血糖、餐后2 h血糖、收缩压/舒张压及低密度脂蛋白的变化情况,并比较不同民族间各项指标的变化情况。结果利拉鲁肽+盐酸二甲双胍组肥胖T2DM患者治疗后3、6个月时的BMI、HBA1c、WHR、空腹血糖及餐后2 h血糖较治疗前均下降,且下降的幅度高于盐酸二甲双胍组,差异具有统计学意义(P<0.05);利拉鲁肽+二甲双胍组肥胖T2DM患者治疗后3、6个月时的收缩压/舒张压、低密度脂蛋白较治疗前均有所下降,但下降幅度偏小,两组比较差异无统计学意义(P>0.05)。利拉鲁肽+盐酸二甲双胍组维吾尔族患者治疗后3、6个月时的BMI、HBA1c、WHR、空腹血糖及餐后2 h血糖较治疗前均下降,且下降的幅度大于汉族患者,差异具有统计学意义(P<0.05)。结论利拉鲁肽联合盐酸二甲双胍在降低肥胖T2DM患者的BMI、HBA1c、WHR、空腹血糖及餐后2 h血糖要优于单用二甲双胍,可作为肥胖T2DM患者的优选治疗方案;利拉鲁肽联合二甲双胍治疗方案对维吾尔族肥胖T2DM患者效果明显,可作为其降糖的优先治疗方案。更多还原

【Abstract】 Objective Observation of clinical effects of liraglutide combined with mefformin on type 2 diabetes mellitus with obesity. Methods The randomized and controlled open-label trial involved 132 patients with obesity and type 2 diabetes,who were randomly assigned to groups of receiving Liraglutide combined with mefformin( n =66,uygur = 21,han = 45) or mefformin alone( n = 66,uygur = 29,han = 37) for 24 weeks. The changes of BMI,HBA1 c,waist-hip ratio,fasting glucose treatment,postprandial blood sugar 2 hours,systolic / diastolic blood pressure and low density lipoprotein cholesterol before the treatment and after treatment of 3 months or 6 months were compared. And,the indexes above of different nationalities were compared too. Results After treatment for 3months or 6 months,BMI,HBA1 c,waist-hip ratio,fasting glucose treatment and postprandial blood sugar 2 hours of the experimental group were decreased than that of the control group( P < 0. 05). The systolic / diastolic blood pressure and low density lipoprotein cholesterol( hdl-c) of experimental group were declined,but the small decline compared with that of the control group and no statistical difference( P > 0. 05). After treatment,the BMI,HBA1 c,waist-hip ratio,fasting glucose treatment,postprandial blood sugar 2 hours of Uygur was improved greater than that of the Han( P <0. 05). Conclusion The effects of Liraglutide combined with mefformin is superior to metformin only,and could be used as optimization of obese patients with T2 DM treatment,and especially for the Uygur.更多还原