【摘要】 目的提高对原发性膀胱印戒细胞癌(primary bladder signet-ring cell carcinoma,PBSRCC)的诊疗认识。方法通过对2例原发性膀胱印戒细胞癌临床病例资料的分析,并结合文献进行复习讨论。结果术前2例患者行B超、脱落细胞、CTU、膀胱镜等检查明确为膀胱占位。行膀胱全切术手术治疗后,病理结果显示为膀胱印戒细胞癌,并行相关检查排除转移性肿瘤。1例予以GC方案化疗,4周后行自体细胞免疫回输(CIK)治疗,术后6个月死于广泛转移。另1例未行化疗,随访至今2个月无复发及转移。结论原发性膀胱印戒细胞癌较罕见,主要依靠影像学检查发现,临床确诊主要依靠病理检测。手术治疗是最主要的治疗方法,辅助化学治疗药物的作用及疗效还有待继续临床研究。更多还原

【Abstract】 Objective To improve the understanding of diagnosis and treatment on primary bladder signet-ring cell carcinoma(PBSRCC). Methods Two cases of primary signet ring cell carcinoma of the bladder were studied and the literature was reviewed. Results The two patients received ultrasound, urinary cytology, computerized tomography, and cystoscopy pre-operation, and radical cystectomy was performed. Two cases were diagnosed as PBSRCC after surgical pathology. Chemotherapy was delivered after surgery in one case, after 4 weeks, the patient was treated with autologous cytokine induced killer cells(CIK) and died at 6 months postoperatively because of multiple metastasis. No chemotherapy treatment was performed in another case. No recurrence or metastasis was observed 2 months after discharge. Conclusion PBSRCC is a rare malignant tumor with poor prognosis. Imaging examination is helpful for its diagnosis, and final diagnosis is made by post-operation pathology. Radical cystectomy is the main effective treatment and the effects of adjuvant chemotherapy are to be of clinical research.更多还原