【摘要】 [目的]评价食管癌外照射放疗后腔内后装加量治疗的不良反应,并分析其治疗疗效。[方法]回顾性分析初诊食管鳞癌患者27例,外照射放疗1~2周后采用192铱腔内后装加量,外照射放疗剂量50~67Gy/25~33f,腔内后装放疗剂量4~10Gy/1~2f,其中16例患者联合化疗。[结果]全组患者近期疗效评价有效率100%,其中CR 15例(55.6%),PR 12例(44.4%)。Ⅲ级以上放射性食管炎和血液学毒性分别为1例(3.7%)和6例(22.2%),无食管穿孔及大出血发生。随访中位时间为35个月,至随访截止时食管局部复发4例,死亡6例,2年局部控制率为84.7%,2年和3年生存率分别为88.9%和78.9%。[结论]食管癌外照射放疗后腔内后装加量治疗可耐受,并能获得较好的治疗疗效。更多还原

【Abstract】 [Purpose]To investigate the toxicity and efficacy of intracavitary brachytherapy boost following external irradiation for esophageal cancer. [Methods] Twenty-seven patients with esophageal cancer were retrospectively reviewed. All patients received radiotherapy consisting of external irradiation to a total dose of 50 ~67Gy in 25 ~33 fractions,followed by brachytherapy to4~10Gy in 1~2 fractions. Sixteen cases also received chemotherapy. [Results] The complete response and partial response rate were 55.6% and 44.4%,respectively. Grade 3 or higher than acute toxicities occurred in 7 cases,including esophagitis(1 case) and hematologic toxicities(6cases). No acute esophageal bleeding and fistula occurred during treatment period. The median follow-up time was 35 months. Up to the deadline of follow-up,there were 4 cases of local recurrence and 6 cases died. The 2-year local control rate was 84.7%. The overall survival rate at 2and 3 years were 88.9% and 78.9%,respectively.[Conclusion] Combined external irradiation and brachytherapy boost for esophageal cancer is tolerable,and can produce favorable local control and survival rates.更多还原