【摘要】 目的 :分析不同剂量辛伐他汀对冠状动脉粥样硬化症患者血管内皮细胞功能影响,探讨其作用机制。方法 :选取我院2010年6月~2014年6月收治的528例冠状动脉粥样硬化症患者,按照其低密度脂蛋白胆固醇(LDL-C)水平分为A组(LDL-C≥4.16 mmol/L)、B组(3.64 mmol/L≤LDL-C<4.16 mmol/L)、C组(2.60 mmol/L≤LDL-C<3.64 mmol/L)及D组(LDL-C<2.60mmol/L),使用不同剂量辛伐他汀进行治疗。观察其治疗前后血管内皮功能变化。结果:治疗前A、B、C三组患者TC、LDL-C水平显著高于D组(P<0.05),各组TG、HDL-C、血清NO水平比较无明显统计学差异(P>0.05)。治疗后A、B、C三组患者TC、LDL-C水平显著降低,血清NO水平显著升高(P<0.05),其TC、LDL-C水平与D组患者比较无明显统计学差异(P>0.05)。治疗前后各组患者肱动脉基础内经、NMD均未见明显改变(P>0.05),治疗后A、B、C三组患者FMD均显著升高(P<0.05),D组患者FMD未见明显改变(P>0.05)。结论 :针对冠状动脉粥样硬化症患者血清LDL-C水平选择合适剂量的辛伐他汀有助于提升其血清NO水平,改善血管内皮细胞功能。更多还原

【Abstract】 Objective:To analyze the effect of different doses of simvastatin on endothelium function in patients with coronary atherosclerosis,and to explore its mechanism of action.Methods:The 528 cases of coronary atherosclerosis patients were divided into 4 groups in according to the level of low density lipoprotein cholesterol(LDL-C):group A(LDL-C≥4.16 mmol/L),group B(3.64 mmol/L≤LDL-C<4.16mmol/L),group C(2.60,mmol/L≤LDL-C<3.64 mmol/L) and group D(LDL-C≤2.60 mmol/L).All the patients were treated with different doses of simvastatin.Then observed the changes of vascular endothelial function before and after treatment of all gourps.Results:Before treatment,the TC,LDL-C levels of A,B,C groups of patients were significantly higher than that of D group(P<0.05).After treatment,TC,LDL-C level of A,B,C groups of patients were significantly decreased,which were no significant differences with group D,and the level of serum NO was significantly increased(P<0.05).Before and after treatment in each group,the brachial artery and NMD in patients showed no obvious change(P>0.05).After treatment,the FMD of A,B,C groups of patients were significantly increased(P<0.05),but D group of patients with FMD had no obvious change(P>0.05).Conclusion:According to the serum LDL-C level in patients with coronary atherosclerosis and select the appropriate dose of simvastatin helps to enhance the serum level of NO,and to improve the function of vascular endothelial cells.更多还原