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胃腺癌组织中P33ING1b、FXYD3、PINCH蛋白的相关性分析

Correlation analysis of P33ING1b, FXYD3 and PINCH protein in gastric adenocarcinoma

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【作者】 杨艳红朱振龙

【Author】 YANG Yan-hong;ZHU Zhen-long;Pathology department, first hospital of Hebei medical university;

【机构】 河北医科大学第一医院病理科

【摘要】 目的探讨P33ING1b、FXYD3、PINCH蛋白在胃腺癌组织中的表达及意义。方法采用免疫组化SP法,检测P33ING1b、FXYD3、PINCH在30例正常胃黏膜及73例胃腺癌组织中的表达,并分析其与临床病理特征之间的关系及相关性。结果 P33ING1b蛋白的阳性表达与PINCH蛋白的阳性表达之间趋于存在正相关关系(r=0.279,P=0.007);胃腺癌中FXYD3蛋白的阳性表达与P33ING1b蛋白的阳性表达之间并无相关性(r=0.131,P=0.257)。结论 P33ING1b蛋白在胃腺癌细胞胞质中的表达,可能更方便通过细胞内、外的信息传递而与间质中表达的PINCH蛋白相互作用,共同参与肿瘤的发生。

【Abstract】 Objective The aim of this study was to investigate the expression of P33ING1 b, FXYD3 and PINCH protein in gastric adenocarcinoma, and to analyze the significance. Methods SP immunohistochemical method was used to detect the expression of P33ING1 b, FXYD3 and PINCH in 30 cases of normal gastric mucosa tissue, as well as in 73 cases of gastric adenocarcinoma. Results P33ING1 bprotein positive expression and PINCH protein positive expression tend to show a positive correlation relationship(r=0.279,P=0.007); FXYD3 protein positive expression in gastric adenocarcinoma had no correlation with the positive expression of P33ING1 b protein(r=0.131, P=0.257). Conclusion P33ING1 bprotein expression was found in gastric cancer cell cytoplasm, leading to more convenient internal and external information transmission and stroma in the expression of PINCH protein interaction, which participated in the tumor pathogensis.

【基金】 河北省卫生厅课题(20130561)
  • 【文献出处】 现代预防医学 ,Modern Preventive Medicine , 编辑部邮箱 ,2015年14期
  • 【分类号】R735.2
  • 【被引频次】2
  • 【下载频次】36
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