【摘要】 背景:骨代谢与肠道菌群肠道内定植了数量众多、种类丰富的肠道菌群,它们和宿主间形成了互利共生的关系,对宿主的健康产生着重大影响。研究发现肠道菌群不仅调控肠道活动,并且能通过调节免疫系统状态进而干预骨代谢。目的:综述肠道菌群对骨代谢影响研究的新进展。方法:以"Gut microbiota,immunesystem,bonemetabolism,osteoporosis"为关键词检索Pub Med数据库,选择内容与肠道菌群、免疫及骨代谢相关文献,同一领域文献则选择近期发表或发表在权威杂志文章。最总共纳入文献46篇,从肠道菌群与免疫、骨代谢与免疫、肠道菌群与骨代谢3方面进行综述。结果与结论:肠道菌群对骨质疏松症的影响研究将涉及到骨生理学、肠胃病学、免疫学以及微生物学等多门学科。无菌小鼠与人体内实验研究发现肠道菌群对骨代谢具有重要影响,利用抗生素、益生菌、益生元干预肠道菌群进一步证实了肠道菌群对骨量具有很好的调节作用。这些作用主要表现在迅速生长期,例如骨量需求较大的青春期,以及骨量丢失较明显的妇女更年期。更多还原

【Abstract】 BACKGROUND: The gut microbiota in our intestine performs numerous useful functions and has a major impact on the host’s health. Recently some studies have revealed that the gut microbiota cannot only control intestinal activity but also affect bone metabolism by regulating the immune system. OBJECTIVE: To review the new research development in the effects of gut microbiota on bone metabolism. METHODS: We retrieved the PubM ed database using "gut microbiota, immune system, bone metabolism, osteoporosis" as keywords. A total of 46 articles were included which were related to gut microbiota, immune system and bone metabolism. For the articles in the same field, those published recently or in authorized journals were selected. RESULTS AND CONCLUSION: Gut microbiota-osteoporosis research will bridge the gaps between bone physiology, gastroenterology, immunology, and microbiology. In vivo experiments in the germ-free mice and human body have found that the gut microbiota has important effects on bone metabolism, and the intervention of antibiotics, probiotics and prebiotics has further confirmed the effects of gut microbiota on bone mass. The gut microbiota has more obvious effects on bone mass in the adolescent and post-menopause periods.更多还原