【摘要】 背景:骨细胞的分化与瘦素存在着明显的关联已被一些研究证明,动物实验也证实,瘦素间接通过中枢神经系统抑制成骨细胞的形成,但也对成骨细胞的骨微环境中的合成代谢有一定的影响。目的:分析新疆地区老年女性骨量减少患者血清瘦素水平的变化及其与骨密度及骨转换相关生化指标的关系。方法:选择新疆维吾尔自治区居住30年以上、年龄≥60岁的老年女性,其中74例为骨质疏松者,111例为骨量减少者;191例为骨量正常者。采用酶联免疫法(ELISA)检测各组受试者血清瘦素、骨碱性磷酸酶等指标。结果与结论:体质量指数值、瘦素值骨质疏松组明显低于正常组(P<0.01),骨量减少组明显低于正常组(P<0.05);所有部位的骨密度,骨质疏松组明显低于骨量减少组和正常组(P<0.01);骨量减少组明显低于正常组(P<0.01)。老年女性骨质疏松患者血清瘦素水平与患者正位腰椎、左侧髋关节骨密度呈明显正相关(r=0.870,r=0.468,均P<0.01);骨量减少患者血清瘦素水平与患者正位腰椎、左侧髋关节骨密度呈明显正相关(r=0.477,r=0.467,均P<0.01)。骨质疏松患者血清瘦素与体质量指数呈明显正相关(r=0.502,P<0.01)。结果提示,血清瘦素水平降低在新疆地区老年女性骨质疏松和骨量减少的发病中可能发挥重要作用。更多还原

【Abstract】 BACKGROUND: Some studies have demonstrated that there is a clear correlation between osteocyte differentiation and leptin. Animal experiments have also confirmed that leptin indirectly inhibits the formation of osteoblasts through the central nervous system, but it also has some influences on the anabolism in bone microenvironment of osteoblasts. OBJECTIVE: To analyze the variation of serum leptin levels in older female patients with osteopenia, and the relationship between serum leptin levels, bone mineral density and related biochemical indexes of bone turnover. METHODS: The older female patients, aged ≥ 60 years, who had lived in Xinjiang Uygur Autonomous Region for more than 30 years, were selected. Among these patients, 74 had osteoporosis, 111 had osteopenia, and 191 had normal bone mass. Serum leptin levels, bone alkaline phosphatase and other indicators of the patients were detected using enzyme-linked immunoassay method. RESULTS AND CONCLUSION: Compared with the normal group, the body mass index value and leptin level were significantly lower in the osteoporosis group(P < 0.01) and in the osteopenia group(P < 0.05). The bone mineral densities of all parts of patients in the osteoporosis group were lower than those in the osteopenia and normal groups(P < 0.01), and the bone mineral density value of patients in the ostopenia group was significantly lower than that in the normal group(P < 0.01). The serum leptin levels of older female patients with osteoporosis were significantly positively correlated with the bone mineral density value of the anteroposterior lumbar spine and the left hip bone(r=0.870, r=0.468, P < 0.01). The serum leptin levels of older female patients with osteopenia were significantly positively correlated with the bone mineral density value of the anteroposterior lumbar spine and the left hip(r=0.477, r=0.467, P < 0.01). The serum leptin levels of older female patients with osteoporosis were significantly positively correlated with body mass index(r=0.502, P < 0.01). These results suggest that reduced levels of serum leptin may play an important role in the pathogenesis of osteoporosis and osteopenia in older female patients in Xinjiang Uygur Autonomous Region, China.更多还原