【摘要】 背景:研究已证实重组人表皮生长因子具有促进肉牙组织形成、加快烧伤创面愈合的作用,但重组人表皮生长因子的抗菌作用有限。目的:观察重组人表皮生长因子凝胶联合纳米银敷料治疗烧伤的效果及对瘢痕的作用。方法:纳入浅Ⅱ度及深Ⅱ度烧伤患者76例,随机均分为两组,研究组将重组人表皮生长因子涂于创面表面,并以纳米银敷料覆盖;对照组将重组人表皮生长因子涂于创面表面,并以普通无菌纱布覆盖。比较两组创面愈合时间、细菌阳性率、瘢痕情况及不良反应。结果与结论:研究组创面愈合时间、创面愈合后增生瘢痕率均低于对照组(P<0.01),创面愈合后扁平瘢痕率高于对照组(P<0.01),治疗后7,14,21 d创面细菌阳性率显著低于对照组(P<0.05)。两组过敏反应及局部烧灼感发生率比较差异无显著性意义(P>0.05)。表明重组人表皮生长因子凝胶联合纳米银敷料治疗烧伤具有较好的疗效,可加速创面愈合,减少瘢痕增生,提高美观度。更多还原

【Abstract】 BACKGROUND: Recombinant human epidermal growth factor has been shown to promote granulation tissue formation and to accelerate the healing of burn wounds, but the antibacterial effect of recombinant human epidermal growth factor is limited. OBJECTIVE: To investigate the effect of nano-silver dressing combined with recombinant human epidermal growth factor gel in treatment of burns and the influence on the scar. METHODS: A total of 76 cases of shallow II and depth II degree were randomly enrolled and assigned to two groups. In the study group, recombinant human epidermal growth factor was coated on the surface of the wound,and then covered by nano-silver dressing. In the control group, recombinant human epidermal growth factor was coated on the surface of the wound, and covered by ordinary sterile gauze. The healing time, the positive rate of bacteria, scarring and adverse reactions were compared between the two groups. RESULTS AND CONCLUSION: The wound healing time and the rate of hypertrophic scars after healing were lower in the study group than in the control group(P < 0.01). The rate of flat scar was greater in the study group than in the control group after healing(P < 0.01). The bacterial positive rate was significantly lower in the study group than in the control group at 7, 14 and 21 days after treatment(P < 0.05). No significant difference inincidence of allergies and local burning sensation was detected between the two groups(P > 0.05). These data confirmed that recombinant human epidermal growth factor gel combined with nano-silver dressing in the treatment of burn has good efficacy and accelerates the wound healing, reduces scar formation, and improves aesthetics.更多还原