【摘要】 背景:磺胺嘧啶银脂质水胶敷料是两种抗菌药物的结合体,可以发挥局部广谱、强效、持久的抗菌作用,能有效控制并预防伤口感染。目的:观察磺胺嘧啶银脂质水胶敷料治疗皮肤缺损性感染伤口的效果及生物相容性。方法:将30例皮肤缺损合并感染伤口患者采用随机分组方法分为观察组和对照组,两组均常规清创、换药后,观察组用生理盐水冲洗伤口后使用磺胺嘧啶银脂质水胶敷料覆盖,再以纱布包扎;对照组使用凡士林纱布覆盖后再以纱布包扎。观察两组治疗0,1,2周换药时的目测类比评分、敷料与伤口粘连情况、创面愈合率及痊愈时间。结果与结论:观察组治疗1,2周换药时的目测类比评分显著低于对照组(P<0.01),治疗1,2周换药时的创面愈合率显著高于对照组(P<0.05);观察组换药时敷料与伤口粘连情况明显少于对照组(P<0.01),创面愈合时间明显短于对照组(P<0.05)。表明磺胺嘧啶银脂质水胶敷料治疗皮肤缺损合并感染伤口效果好,可减轻换药时疼痛,有效控制感染,促进伤口愈合。更多还原

【Abstract】 BACKGROUND:Silver sulfadiazine water gel dressings are a combination of two antibacterial drugs,which can play a local broad-spectrum,potent,long-lasting antibacterial effect to effectively control and prevent wound infection.OBJECTIVE:To observe the clinical efficacy of silver sulfadiazine water gel dressings on skin defects with wound infection and to explore its biocompatibility.METHODS:Thirty patients with skin defects combined with wound infection were randomized into observation and control groups. Following conventional debridement and dressing,the observation group was subject to wound rinse with normal saline,silver sulfadiazine water gel dressings and gauze bandage; in the control group,Vaseline gauze was used followed by gauze bandage. Visual analog scale scores,dressing adhesion to wound,wound healing rate,and healing time were observed in the two groups at 0,1,2 weeks after dressing.RESULTS AND CONCLUSION:The visual analog scale scores in the observation group were significantly lower than those in the control group at 1 and 2 weeks after dressing(P < 0.01),and the wound healing rate was also higher in the observation group than the control group(P < 0.05); wound adhesions were milder in the observation group than the control group when dressing; the healing time was significantly shorter in the observation group than the control group(P < 0.05). These findings suggest that the silver sulfadiazine water gel dressing has good effects on the treatment of skin defects with wound infection,which can reduce pain,effectively control wound infections and promote wound healing.更多还原