【摘要】 目的评价康肾汤治疗慢性肾脏病(CKD)2~3期患者的临床疗效与安全性。方法将96例慢性肾脏病2~3期患者随机分为2组,康肾汤组48例在西医常规治疗基础上同时给予康肾汤治疗,对照组48例仅给予西医常规治疗,2组均连续治疗6个月。观察2组治疗前后血肌酐(SCr)、估算肾小球滤过率(e GFR)、超敏C反应蛋白(hs-CRP)、白细胞介素-17(IL-17)、干扰素-γ(IFN-γ)、血红蛋白、血浆白蛋白及ALT的变化。结果对照组治疗后SCr、e GFR水平与治疗前比较差异均无统计学意义(P均>0.05),康肾汤组治疗后SCr、e GFR水平较治疗前及对照组明显改善(P均<0.05)。2组治疗前后血红蛋白、血浆白蛋白、ALT水平比较差异均无统计学意义。治疗后康肾汤组hs-CRP水平较较治疗前明显下降(P<0.05),而对照组较治疗前明显升高(P<0.05),康肾汤组明显低于对照组(P<0.05);2组治疗后IFN-γ、IL-17水平均较治疗前明显下降(P均<0.05),且康肾汤组水平明显低于对照组(P均<0.05)。结论康肾汤能明显改善慢性肾脏病2~3期患者的微炎症状态及肾功能,并具有较好的安全性。更多还原

【Abstract】 Objective It is to observe the clinical efficacy and safety of Kangshen decoction on stage 2- 3 chronic kidney disease( CKD) patients. Methods 96 cases of stage 2- 3 CKD patients were randomly divided into Kangshen decoction group( n = 48) treated with normal western medicine combined with Kangshen decoction and the control group( n = 48) treated with western medicine alone,both groups were treated for 6 months. The changes of SCr,e GFR,hs- CRP,IL- 17,IFN- γ,Hb,plasma albumin and ALT were observed before and after treatment in both groups. Results Compared with that before treatment,the differences in the levels of SCr and e GFR in control group were not significant( P > 0. 05),but the levels in Kangshen decoction group were both improved obviously compared with that before treatment and in control group( P < 0. 05).There was no significant difference in the levels of Hb,plasma albumin and ALT in both groups before and after treatment.The level of hs- CRP was significantly decreased in Kangshen decoction group after treatment compared with that before treatment( P < 0. 05),but that in control group showed an obvious increase after treatment and was significantly higher than that before treatment and in Kangshen decoction group after treatment( P < 0. 05). Compared with the pre-treatment,IL- 17 and IFN- γ were significantly decreased in control group and Kangshen decoction group,and the levels in Kangshen decoction group were more lower than that in control group after treatment( P < 0. 05). Conclusion Kangshen decoction can significantly improve micro-inflammatory state and renal function with a reliable security in stage 2- 3 CKD patients.更多还原