【摘要】 目的通过对新疆艾滋病病毒(HIV)感染者的病毒基因序列分析,了解2010-2013年新疆HIV亚型和耐药传播情况。方法采集当年新报告的16~25岁未接受抗病毒治疗的HIV-1感染者的血浆样本,提取病毒核糖核酸(RNA),通过扩增HIV-1 pol区片段,进行测序和耐药基因变异分析。结果 4年共获得pol区序列150条,主要以CRF07_BC为主(96.7%,145/150),共有3例出现耐药,分别针对非核苷类抑制剂(NNRTIs)和核苷类抑制剂(NRTIs)。耐药株主要出现在性传播人群中。结论各传播途径中仍主要流行CRF07_BC,新疆HIV-1耐药传播目前处于低度传播水平,但仍需进一步加强对感染者的耐药监测和病人的治疗管理。更多还原

【Abstract】 Objective To understand HIV subtypes and drug-resistance transmission in Xinjiang in 2010-2013 through viral sequence analysis in HIV infected patients in Xinjiang.Methods Blood samples were collected from antiretroviral naive HIV infected patients aged 16 to 25years newly reported in the current year.Viral RNA was extracted.HIV-1pol was amplified sequenced to analyze drug resistance gene mutation.Results A total of 150 sequences of pol gene were gotten within 4years,predominated by CRF07_BC(96.7%,145/150).A total of 3cases were drug resistant to nucleoside inhibitors(NNRTIs)and nucleoside inhibitors(NRTIs),which mainly appeared in sexually transmitted population.Conclusion CRF07_BC is still the main subtype in each route of transmission.Drug-resistance transmission of HIV-1in Xinjiang is at a low level,but it is still needed to further strengthen drug resistance monitoring and treatment management of HIV/AIDS patients.更多还原