【摘要】 目的:探讨帕金森病合并快速动眼期异态睡眠(RBD)与认知功能障碍之间的关系。方法:收集2012年5月至2014年11月就诊于我院神经内科的54例帕金森病患者,其中帕金森病合并RBD组(PD-RBD组)25例,未合并RBD组(PD-NRBD组)29例,另收集社区健康对照组21例。所有受试者均完成2夜整夜视频多导睡眠监测、统一帕金森病量表I(UP-DRSI)、Hoehn-Yahr分期、蒙特利尔认知评估量表(Mo CA)、爱泼沃斯思睡量表(ESS)的评测。结果:1PD-RBD组注意力与计算力、视空间及执行功能、延迟记忆的得分明显低于PD-NRBD组和健康对照组,差异有统计学意义(均P<0.05);2PD-RBD组和PD-NRBD组睡眠效率较健康对照组低,合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)及不宁腿综合征发病率高,差异有统计学意义(P<0.05);3PD-RBD组和PD-NRBD组间睡眠效率及其他睡眠合并症差异无统计学意义(P>0.05)。结论:帕金森病患者合并RBD与认知功能障碍相关,RBD可以作为帕金森病患者认知功能障碍的预测因素。更多还原

【Abstract】 Objective: To investigate the correlation between rapid-eye-movement sleep behavior disorder(RBD) and the cognitive impairment in patients with Pakinson disease(PD). Methods: Fifty-four patients with Parkinson disease were enrolled from Neurology Department of Lishui Central Hospital from 2012 to 2013(25 PD-RBD cases and 29 PD-NRBD cases), with 21 healthy participants as the control group. Full-night videopolysomnography(v PSG) for two nights, Unified Parkinson Disease Rating Scale(UPDRS-III) Questionaire, Hoehn-Yahr stage criteria, Montreal Cognitive Assessment(Mo CA) and The Epworth Sleepiness Scale(ESS) were performed on all study participants. Results: The score for attention and calculation, visual-spatial and its congitive function, delayed memory in PD-RBD group were all significantly lower than that in PD-NRBD group and control group(P<0.05). Sleep efficiency in both PD-RBD and PD-NRBD group were lower than that in control group, and often accompanied by obstructive sleep apnea-hypopnea syndrome and restless leg syndrome(P<0.05). There was no statistical significant difference between the two PD groups(P>0.05). Conclusion: Parkinson disease patients combined with RBD are correlated with cognitive dysfunction. RBD can be used as a predictor for cognition impairment in Parkinson disease.更多还原