【摘要】 目的了解菰米的血糖生成指数(GI),观察菰米对高脂饲料诱导的胰岛素抵抗(IR)大鼠的作用。方法以50 g葡萄糖为对照,测定健康成人(n=8)食用67 g菰米后2 h内的血糖水平,并根据Wolver方法计算菰米GI。50只雄性SD大鼠随机分成阴性对照组、IR模型组、高剂量菰米组、低剂量菰米组和米面组,喂养8周,测定大鼠空腹血糖(FPG)、空腹胰岛素(INS)、糖化血红蛋白(Hb A1c)和胰高血糖素(GC),计算胰岛素抵抗指数(HOMA-IR)。结果菰米的GI为53.72。IR模型组和米面组大鼠体重、FPG、INS、GC水平和HOMA-IR均高于阴性对照组(P<0.05);与IR模型组和米面组相比,高剂量菰米组和低剂量菰米组大鼠体重降低,FPG、INS、GC水平和HOMA-IR均显著下降(P<0.05);低剂量菰米组大鼠血清FPG、INS、GC水平略高于阴性对照组和高剂量菰米组,但差异无统计学意义。结论菰米属于低血糖生成指数食物,同时菰米能改善高脂饲料诱导的大鼠胰岛素抵抗,用菰米替代50%的精米面能改善大鼠的胰岛素抵抗状态。更多还原

【Abstract】 Objective To investigate the glycemic index( GI) of wild rice,and observe the effects of wild rice on the insulin resistance( IR) rats induced by high fat diet. Methods With 50 g glucose as control,measured healthy adults( n = 8) blood glucose levels after eating 67 g wild rice within 2 h,and using Jenkins and Wolever formula to calculate the GI. 50 male SD rats were randomly divided into negative control group,IR model group,high-dose of wild rice group,low-dose of wild rice group and white rice-flour group,continuous feeding eight weeks. Fasting blood glucose( FPG),fasting insulin( INS),glycosylated hemoglobin( Hb A1c) and glucagon( GC) were measured,and insulin resistance index( HOMA-IR) was calculated. Results The GI of wild rice was 53. 72. Compared with the negative control group,the rats of IR model group and white rice-flour group had higher body weight,FPG,INS,GC levels and HOMA-IR( P < 0. 05). Compared with the white rice-flour and IR model group,FPG,INS,GC levels and HOMA-IR in rats fed high-dose of wild rice and low-dose of wild ricediet were significantly decreased( P < 0. 05). The rats fed with low-dose of wild rice diet had slightly increased FPG,INS,GC levels and HOMA-IR,but the difference was not statistically significant. Conclusion Wild rice is a low glycemic index food,while wild rice can improve the resistance in rats induced by high fat diet,and replace 50% of the refined rice and flour with wild rice can improve insulin resistance in rats.更多还原