【摘要】 脂肽类抗生素是由微生物代谢产生的一类具有很强表面活性的生物活性物质,含有由亲水性氨基酸和疏水性脂肪酸链组成的特殊分子结构,表现出亲水、亲脂两亲性的特性,具有抗菌、抗肿瘤和抗病毒等多种生物学活性,作为抗菌药物和肿瘤抑制剂在医药和临床应用领域具有良好的应用潜力和前景。本文对脂肽类抗生素的结构、生物学功能和作用机制等最新研究进展进行综述。更多还原

【Abstract】 Lipopeptide antibiotics are kinds of important antibacterial material with strong surface activity typically synthesized by microorganisms,especially by Bacillus. It contains special molecular structure composed of hydrophilic amino acids and hydrophobic fatty acid chains that shows amphipathic features. Lipopeptide antibiotics possesse antibacterial,antifungal,antiviral and antitumor activities,and other multiple bio-activities. As antibiotic medicine and tumor inhibition preparations lipopeptide antibiotics have potential application and outlook in the fields of medicines and clinics. Advances in the structure characteristics,biological function and action mechanism were reviewed in this paper.更多还原