Objective: To assess the diagnostic value by combined detecting the glucose transporter protein 1( GLUT1) and the tight junction protein( claudin-4) in the pleural effusion in patients with metastatic adenocarcionoma of lung and reactive mesothelial cells. Methods: Immunohistochemistry was used to detect the expression of GLUT1 and claudin-4 in pleural effusion in 30 patients with adenocarcinoma of lung and 25 with reactive mesothelial cells,and the sensitivity and specificity were compared between combined...