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硫化氢与消化道动力的研究进展
Advances in Study on Hydrogen Sulfide and Gastrointestinal Motility
【摘要】 消化道可产生硫化氢(H2S),胱硫醚-β-合成酶(CBS)、胱硫醚-γ-裂解酶(CSE)是内源性H2S合成的关键酶。H2S可调节消化道动力,主要表现为抑制肠道动力,对胃动力具有双重调节作用,其机制可能与肠Cajal间质细胞、平滑肌、肠神经细胞相关。本文就H2S与消化道动力的研究进展作一综述。
【Abstract】 Hydrogen sulfide( H2S) can be synthesized in gastrointestinal tract. Cystathionine-β-synthase( CBS) and cystathionine-γ-lyase( CSE) are two important enzymes for synthesis of endogenous H2 S. H2 S may play an important role in regulating gastrointestinal motility. H2 S can inhibit intestinal motility and has dual effect on gastric motility. The mechanism of the effect of H2 S may be related to interstitial cells of Cajal,smooth muscles and intestinal neurons. This article reviewed the advances in study on H2 S and gastrointestinal motility.
【关键词】 硫化氢;
胃肠活动;
胱硫醚β合酶;
胱硫醚γ裂合酶;
【Key words】 Hydrogen Sulfide; Gastrointestinal Motility; Cystathionine beta-Synthase; Cystathionine gamma-Lyase;
【Key words】 Hydrogen Sulfide; Gastrointestinal Motility; Cystathionine beta-Synthase; Cystathionine gamma-Lyase;
【基金】 广西壮族自治区卫生厅计划科研课题(Z2012408)资助
- 【文献出处】 胃肠病学 ,Chinese Journal of Gastroenterology , 编辑部邮箱 ,2015年01期
- 【分类号】R57
- 【被引频次】5
- 【下载频次】171