【摘要】 目的探讨银杏叶制剂联合盐酸多奈哌齐对老年轻度认知功能障碍疗效的影响。方法采用随机数字表法将2011年3月-2013年3月在日照市精神卫生中心治疗的112例符合2006年中国防治认知功能障碍专家共识诊断标准的轻度认知功能障碍的老年患者分为对照组和实验组各56例。对照组给予银杏叶制剂治疗,每次口服19.2g,每日3次,12个月为一个疗程。实验组给予银杏叶制剂联合盐酸多奈哌齐治疗,银杏叶制剂治疗方案同对照组,盐酸多奈哌齐每次口服5mg,每日服药1次,治疗一月后每次服药10mg。采用阿尔茨海默病评定量表认知分量表(ADAS-cog)、简易精神状态量表(MMSE)及脑电图(EEG)测评治疗效果、异常率、P300潜伏值和波幅变化。结果实验组总有效率85.72%,高于对照组67.86%,差异有统计学意义(P<0.05)。实验组治疗前及治疗后1、3、6、12个月MMSE评分分别为(18.31±4.24)分、(19.95±3.81)分、(23.35±3.25)分、(25.46±2.92)分、(27.47±3.93)分,对照组分别为(18.53±4.92)分、(19.46±3.63)分、(19.97±3.63)分、(20.13±3.01)分、(22.01±3.35)分。治疗前及治疗后1个月两组MMSE评分差异无统计学意义(P>0.05),治疗后3个月、6个月、12个月MMSE实验组评分高于对照组,差异有统计学意义(P<0.05)。实验组P300潜伏期和波幅分别为(332.42±35.81)ms、(13.78±4.21)μV,对照组分别为(397.13±40.93)ms、(7.01±3.75)μV。实验组P300潜伏期较对照组短、波幅高,差异有统计学意义(P<0.05)。结论银杏叶制剂联合盐酸多奈哌齐治疗老年轻度认知功能障碍的效果优于单用银杏叶制剂治疗。更多还原

【Abstract】 Objective To investigate the effects of ginkgo biloba combined with donnell hydrochloride mild cognitive impairment in elderly efficacy. Methods Using a random number table method,112 elderly patients with mild cognitive impairment in 2011March- 2013 March at Rizhao City mental health center of treatment were divided into controlgroup and experimental group with 56cases in each group. The control group was given ginkgo billowy treatment,19. 2g orally,3 times a day,12 months for a course of treatment. The experimental group was given ginkgo billowy donnell hydro chloride,ginkgo billowy treatment with the control group,the effect of donnell hydro chloride each oral 5mg,take the medicine 1 times a day,each time taking 10 mg treatment after one month.Using the Alzheimer’s Disease Assessment Scale cognitive subscale( ADAS- cog),Mini Mental State Examination( MMSE) and electroencephalogram( EEG) of therapeutic effect evaluation,the abnormal rate of P300 latency and amplitude variations,value. Results The total effective rate of the experimental group and the control group were 85. 72% and 67. 86%,the difference was statistically significant( P < 0. 05). The MMSE scores of patients in the experimental group before and 1,3,6,12 months after treatment were( 18. 31± 4. 24) points,( 19. 95 ± 3. 81) points,( 23. 35 ± 3. 25) points,( 25. 46 ± 2. 92) points,( 27. 47 ± 3. 93) points. The control group of patients before and after treatment 1,3,6,12 months after MMSE scores were( 18. 53 ± 4. 92) points,( 19. 46 ± 3. 63)points,( 19. 97 ± 3. 63) points,( 20. 13 ± 3. 01) points,( 22. 01 ± 3. 35) points. After one month of treatment MMSE score between the two groups was not statistically significant( P > 0. 05),the MMSE score of the experimental group after treatment for 3 months,6months,12 months were higher than the control group,the difference was statistically significant before treatment( P < 0. 05). Experimental group P300 latency and amplitude were( 332. 42 ± 35. 81) ms,( 13. 78 ± 4. 21) μV,control patients P300 latency and amplitude were( 397. 13 ± 40. 93) ms,( 7. 01 ± 3. 75) μV. P300 latency in the experimental group than in the control group shortened volatility increased,the difference was statistically significant( P < 0. 05). Conclusion For mild cognitive impairment in elderly patients given ginkgo billowy combined with donnell hydro chloride treatment can significantly improve the therapeutic effect,improve MMSE scores,reduce the rate of EEG abnormalities,shorten P300 latency,increase volatility,elderly with mild cognitive disorder has important clinical significance.更多还原