【摘要】 对丹参酮ⅡA进行结构修饰,合成了羟基丹参酮ⅡA。采用MTT法考察了羟基丹参酮ⅡA对人宫颈癌细胞株Hela细胞,人肝癌细胞株HepG-2细胞、人胃癌细胞株SGC-7901细胞的增殖抑制作用。结果表明:羟基丹参酮ⅡA对三种肿瘤细胞增殖都有很好的抑制作用,抑制作用呈剂量依赖性。羟基丹参酮ⅡA对SGC-7901细胞抑制作用最强,其IC₅₀为4.18μM;对HeLa细胞的抑制作用次之,其IC₅₀为6.08μM;对HepG-2细胞抑制作用较弱,其IC₅₀为10.20μM。而丹参酮ⅡA对SGC-7901细胞、HeLa细胞和HepG-2细胞的IC₅₀分别是17.15μM、27.28μM和46.34μM。羟基丹参酮ⅡA抑制肿瘤细胞增殖作用明显强于丹参酮ⅡA（P<0.05）。更多还原

【Abstract】 Hydroxytanshinone ⅡA was synthesized with tanshinone ⅡA as lead compound.MTT assay was adopted to evaluate its inhibition effect against Hela,HepG-2 and SGC-7901 cells.Results indicated that hydroxytanshinone ⅡA inhibited cell proliferation in a dose-dependent manner.The half inhibitory concentrations(IC₅₀) of hydroxytanshinoneⅡA against SGC-7901,HeLa and HepG-2 cells were 4.18 μM,6.08 μM and 10.20 μM,respectively.But the IC₅₀ of tanshinone ⅡA against SGC-7901,HeLa and HepG-2 cells were 17.15 μM 27.28 μM and 46.34 μM,respectively.The inhibition effect of hydroxytanshinone ⅡA to SGC-7901 cells was powerful.Compared with tanshinone ⅡA,hydroxytanshinone ⅡA significantly increased inhibition effect（P <0.05）.更多还原