【摘要】 以肉桂醛为起始原料,经一锅法不对称环氧化、酯胺缩合和分子内环合三步反应,不对称合成天然产物(+)-balasubramide,总收率为44%,ee值为>99%。其结构经1H NMR、13C NMR、HR-MS和IR确证。本化学合成方法简单,产率较高,为进一步研究该天然产物的生物活性及构效关系奠定一定基础。更多还原

【Abstract】 In this study,( +)-balasubramide was totally synthesized by selecting cinnamaldehyde as starting material with asymmetric epoxidation via one-pot reaction,amine-ester interchange and intramolecular cyclization. Natural product( +)-balasubramide was synthesized with a 44% overall yield and excellent enantioselectivity( > 99%) and confirmed by1 H NMR,13 C NMR,HR-MS and IR. This paper described a convenient and efficient method for the synthesis of natural( +)-balasubramide and laid a certain foundation for the further study of bioactivity and structure-activity relationships of this compound.更多还原