【摘要】 环带小薄孔菌(Antrodiella zonata)发酵液经浓缩、乙酸乙酯萃取后得到浸膏,再用硅胶、RP-18、Sephadex LH-20等材料以及MPLC、HPLC等仪器进行分离纯化,最终利用理化方法和波谱分析进行结构鉴定,从中分离并鉴定了8个化合物,它们分别为薄孔菌素(antrodiellone)(1)、22E-7α-methoxy-5α,6α-epoxyergosta-8(14),22-dien-3β-ol(2)、3β,5α-dihydroxy-6β-methoxyergosta-7,22-diene(3)、6-bromo-1H-indole-3-carboxylic acid ethyl ester(4)、6-bromo-1H-indole-3-carboxylic acid(5)、对羟基苯乙醇(6)、5-羟乙基糠醛(7)、环-(亮-缬)二肽(8)。其中1为新化合物,其余化合物均首次从该种真菌中分离得到。更多还原

【Abstract】 Eight compounds were separated and purified from the ethyl acetate extracts of the fermentation broth of Antrodiella zonata by silica gel,RP-18,Sephadex LH-20 column chromatography,respectively. Their structures were identified as antrodiellone( 1),22E-7α-methoxy-5α,6α-epoxyergosta-8( 14),22-dien-3β-ol( 2),3β,5α-dihydroxy-6β-methoxyergosta-7,22-diene( 3),6-bromo-1H-indole-3-carboxylic acid ethyl ester( 4),6-bromo-1H-indole-3-carboxylic acid( 5),4-hydroxyphenethyl alcohol( 6),5-( 2-hydroxyethyl) furan-2-carboxaldehyde( 7),and cyclo-( L-Leu – L-Val)( 8). 1was a new compound. The other compounds were isolated from A. zonata for the first time.更多还原