【摘要】 目的探讨尿蛋白电泳在狼疮性肾炎和原发性肾病综合征鉴别诊断中的作用。方法对39例狼疮性肾炎和44例原发性肾病综合征患者的流行病学数据、尿蛋白电泳及相关常规实验室检查结果进行卡方检验;分析狼疮性肾炎与原发性肾病综合征患者肾活检病理结果,计算肾小管间质病变评分,进行方差分析。结果患者流行病学数据与既往研究相符,狼疮性肾炎患者混合性蛋白尿发生率及肾小管间质病变评分明显高于原发性肾病综合征患者,但两组患者在高血压发病率及血肌酐升高方面无明显差异。结论蛋白尿电泳有助于鉴别狼疮性肾炎与原发性肾病综合征,并且对肾脏病变的预后有一定指示意义。更多还原

【Abstract】 Objective To explore the role of urine protein electrophoresis in the differentiation diagnosis of lupus nephritis and primary nephrotic syndrome.Methods The epidemiologic data of 39 patients with lupus nephritis and 44 patients with primary nephrotic syndrome were collected and statistically analyzed.The urine protein electrophoresis and relevant routine lab tests were performed,and the!2 test was conducted.Besides,the renal biopsy results of patients with lupus nephritis or primary nephrotic syndrome were analyzed,the tubular-interstitial lesion(TIL)was scored and the variance analysis was preformed.Results The epidemiologic data was consistent with former studies,which revealed that patients with lupus nephritis were more likely to have mixed proteinuria and higher TIL score,but there was no difference in the occurrence of hypertension or serum creatinine increase between the two groups.Conclusion Urine protein electrophoresis can be used for differentiation of lupus nephritis and primary nephrotic syndrome and it might predict the prognosis of renal disease.更多还原