Significance of Normal Range Urinary Albumin to Creatinine Ratio in Chinese Subjects with Metabolic Syndrome

【摘要】 This study was aimed to investigate clinical features of Chinese metabolic syndrome(MS) subjects with normal urinary albumin to creatinine ratio(UACR) and to estimate independent correlation factor for UACR. Data were drawn from a cross-sectional survey in participants having MS. The patients with different grade of albuminuria were divided into 4 groups according to the value of UACR(<10, 10–20, 21–30, >30 mg/g). All underwent biochemical tests. Bioelectrical impedance body fat content, islet β-cell function and insulin sensitivity were measured. Multivariable linear regression models were applied to further determine association between UACR and clinical factors with adjustment. Systolic blood pressure(SBP), diastolic blood pressure(DBP), mean arterial pressure(MAP), fasting plasma glucose(FPG), glycosylated hemoglobin(Hb A1c), TG, fat mass, fat content and homeostasis model assessment for insulin resistance(HOMA-IR) were significantly higher in the group with UACR at 10–20 mg/g than those in the group with UACA lower than 10 mg/g(P<0.05). Multivariable linear regression showed that TG, Hb A1 c, waist-hip ratio(WHR) and SBP were independently associated with UACR. The patients with normal UACR had abnormal levels of MS components. The factors independently associated with UACR were TG, Hb A1 c, WHR and SBP.更多还原

【Abstract】 This study was aimed to investigate clinical features of Chinese metabolic syndrome(MS) subjects with normal urinary albumin to creatinine ratio(UACR) and to estimate independent correlation factor for UACR. Data were drawn from a cross-sectional survey in participants having MS. The patients with different grade of albuminuria were divided into 4 groups according to the value of UACR(<10, 10–20, 21–30, >30 mg/g). All underwent biochemical tests. Bioelectrical impedance body fat content, islet β-cell function and insulin sensitivity were measured. Multivariable linear regression models were applied to further determine association between UACR and clinical factors with adjustment. Systolic blood pressure(SBP), diastolic blood pressure(DBP), mean arterial pressure(MAP), fasting plasma glucose(FPG), glycosylated hemoglobin(Hb A1c), TG, fat mass, fat content and homeostasis model assessment for insulin resistance(HOMA-IR) were significantly higher in the group with UACR at 10–20 mg/g than those in the group with UACA lower than 10 mg/g(P<0.05). Multivariable linear regression showed that TG, Hb A1 c, waist-hip ratio(WHR) and SBP were independently associated with UACR. The patients with normal UACR had abnormal levels of MS components. The factors independently associated with UACR were TG, Hb A1 c, WHR and SBP.更多还原