【摘要】 目的:考查不同配置环境下静脉注射液多药配伍后,放置不同时间,输液不溶性微粒的变化规律,从而为临床输液更加安全、有效提供依据。方法:以5%葡萄糖为溶酶,选取临床常见4个输液配伍处方,分别在静脉药物集中配置中心的洁净环境和病区治疗室半开放式配置环境进行药品冲配;在室温条件下于0.5、1、2、4和8 h时分别取样,应用智能微粒检测仪测定溶液中≥10μm和≥25μm微粒数;将测定结果录入Excel表格中,并进行统计分析。结果:各处方溶液的微粒数均随放置时间的增加有不同程度的增加。普通环境组的4个处方输液微粒数均显著高于洁净环境组(P<0.05或P<0.01);多药配伍后(4联或5联)溶液微粒数显著高于单药冲配(2联)(P<0.05,P<0.01),普通环境下差异更明显。结论:配置环境对输液微粒数的影响较大,输液药物冲配应在静脉药物集中调配中心的洁净环境中进行。输液配伍是决定输液质量的重要因素,配伍种类越多,微粒叠加作用越明显,临床输液最好采用单药配伍。配置好的输液不宜放置太久,应尽早输注。更多还原

【Abstract】 Objective: To find the variation features of insoluble particles in the combined intravenous infusions placed over various periods under different dispensing circumstances to warrant a safe and efficacious use of the drugs. Methods: Four frequently used prescriptions were combined and dissolved in 5% GS under the Dispensing Center for Intravenous infusions( PIVAs) and semi- open treatment area of the ward,respectively. Sampling were taken tested for insoluble particles greater than 10 μm and 25μm at 0. 5,1,2,4,8 h at the room temperature,respectively. Results: The number of the particles in the infusions prepared in the ward was significantly greater than those in the PIVAs( P < 0. 05,P < 0. 01),and increased more rapidly than the latter with the preiod extending( P < 0. 05,P < 0. 01). The more infusions were mixed,the greater the number of particles was. Conclusion: Dispensing circumstances and drug compatibility are the important factors that affect infusion particles,and therefore,injections should be mixed in a clean environment; if drug combination is necessary,the less number of infusions is mixed,the better compatiblity is. The combined infusions should be administered immediately after preparation.更多还原