【摘要】 目的探讨综合干预措施对急性冠脉综合征(acute coronary syndrome,ACS)伴发焦虑抑郁患者生活质量(quality of life,QOL)的影响。方法对218例伴发不同程度焦虑抑郁情绪的ACS患者随机分为常规治疗组(n=109)和干预组(n=109)。对照组扩血管、抗凝、调节血脂、控制心衰、改善心肌重构,干预组在此基础上给予综合性非药物干预包括疾病相关健康讲座、生活方式和运动指导、放松训练、针对性的认知行为治疗。运用一般健康状况评估量表SF-36对所有入组患者定期进行QOL的随访。结果平均随访时间为(10.32±2.11)个月。在SF-36的8个维度中,干预组的生理功能(physiological function,PF)、生理职能(physiological requirement,PR)、躯体疼痛(body pain,BP)、活力(vitality,VT)、精神健康(mental health,MH)评分均高于常规治疗组(P<0.05)。结论对于伴发焦虑抑郁情绪的ACS患者,在常规治疗基础上给予针对性综合干预更有利于改善患者的QOL。更多还原

【Abstract】 Objective To assess the quality of life( QOL) of acute coronary syndrome( ACS) patients complicated with anxiety and depression receiving comprehensive intervention. Methods Two hundred and eighteen ACS patients with anxiety and / or depression symptoms were randomly assigned into intervention group( n = 109) and control group( 109). Both groups received conventional therapy; additional comprehensive intervention,including health education,exercise,psychological relaxation,was given to intervention group. Hospital anxiety depression scale( HADS) and SF-36 scores were assessed before and after intervention. Results After( 10. 32 ± 2. 11) months of follow-up,among 8 domains of SF-36 the scores in physical function( PF),role-physical( RP),bodily pain( BP),vitality( VT) and mental health( MH) were higher than those in control group( P < 0. 05).Conclusion Comprehensive intervention can alleviate anxiety and / or depression symptoms of ACS patients and improve their quality of life.更多还原