【摘要】 目的:探讨血清降钙素原(PCT)和C反应蛋白(CRP)水平检测对脓毒症患者的临床价值。方法:对116例脓毒症患者进行血清PCT、CRP水平检测和APACHEⅡ评分,比较不同病情、存活和死亡患者之间上述3项指标,分析患者血清PCT、CRP水平与APACHEⅡ评分的相关性,并比较不同血清PCT水平患者的死亡率。结果:随着病情的加重,脓毒症患者血清PCT、CRP水平及APACHEⅡ评分逐渐增高(P<0.05);患者血清PCT水平与APACHEⅡ评分呈正相关(r=0.702,P=0.021),血清CRP水平与APACHEⅡ评分呈较弱的正相关性(r=0.216,P=0.045);存活患者血清PCT、CRP水平及APACHEⅡ评分均低于死亡患者(P<0.05);随着血清PCT水平的升高,患者死亡率升高(P<0.05)。结论:血清PCT、CRP检测对脓毒症患者病情判断及预后评估具有一定的临床价值,特别是PCT可作为脓毒症患者血清学检测的重要指标。更多还原

【Abstract】 Objective: To explore clinical value detecting serum procalcitonin( PCT),C reaction protein( CRP)levels in the patients with sepsis. Methods: CPT and CRP level and APACHE II scores were detected in 116 sepsis patients and compared between the survival and dead patients in different conditions. The correlation of the serum PCT,CRP levels with APACHE Ⅱ scores in patients with sepsis was analyzed,also the mortality in patients with different serum PCT levels was compared. Results: The serum PCT,CRP levels and APACHE Ⅱ scores gradually increased along with the progressing of the illness( P < 0. 05); the serum PCT level was positively correlated with APACHE Ⅱ scores in patients with sepsis( r = 0. 702,P = 0. 021),the serum level of CRP had a weak positive correlation with APACHE Ⅱ scores( r = 0. 216,P = 0. 045); The serum PCT,CRP levels and APACHE Ⅱ scores of the survival patients were lower than those of the death patients( P < 0. 05); the mortality increased with the increasing of serum PCT levels in patients( P < 0. 05). Conclusion: Serum PCT and CRP detection has a certain clinical value in early diagnosis and prognosis of the patients with sepsis,especially,PCT can be used as an important index of serological detection in patients with sepsis.更多还原