【摘要】 目的:探讨磁共振评估肝脏铁过载方法的临床价值。方法:搜集49例β-重症地中海贫血患儿进行磁共振肝脏T2*及肝脏铁含量(LIC),以及血清铁蛋白的测定,并经过统计分析3者之间的相关性。结果:肝脏T2*检测49例患儿无铁过载2例(4.0%),轻度铁过载11例(22.4%),中度铁过载31例(63.2%),重度铁过载5例(10.2%)。肝脏LIC检测22例,轻中度铁过载6例(27.3%),重度铁过载16例(72.7%)。血清铁蛋白(SF)水平与肝脏T2*值示存在负相关(r=-0.493,P=0.000);SF水平与LIC示存在正相关(r=0.599,P=0.003)。结论:肝脏磁共振T2*及LIC检测均可以无创、准确评价重症地中海贫血铁过载,具有很好的临床应用价值。更多还原

【Abstract】 Objective To explore the clinical value of magnetic resonance(MR) assessment of liver iron overload. Methods The 49 cases Beta-Thalassemic Major were collected for MR T2 * liver and LIC detection, as well as the determination of serum ferritin, and through statistical analysis of the correlation between the three. Results The liver T2 * 49 cases without iron overload in 2 cases(4.0 %), mild iron overload in 11 cases(22.4 %), moderate iron overload 31 cases(63.2 %), severe iron overload in 5 cases(10.2 %).Liver LIC detection of 22 patients, 6 patients with mild-to-moderate iron overload(27.3 %), severe iron overload in 16 cases(72.7 %).SF levels and liver T2 * values shown there are negative correlation(r =-0. 493, p = 0. 000);SF levels and LIC and shown positive correlation(r = 0.599, p = 0.599).T2 * value and LIC shown there is negative correlation(r = 0.936, p = 0.000). Conclusion The liver magnetic resonance T2 * and LIC can have tested noninvasive and accurate evaluation of severe thalassemia iron overload and has great value in clinical application.更多还原