【摘要】 目的:探讨染色体9p21上7个单核苷酸多态性(SNP)在昆明地区汉族冠心病患者中的表达,及与冠脉病变严重程度的关系。方法:收集2010年12月至2012年12月入住云南省第一人民医院心内科,行冠脉造影术诊断为冠心病的患者200例为冠心病组,同期正常人150例为对照组,采用PCR-SNP Stream技术对rs1333040、rs1333049、rs2383206、rs2383207、rs10116277、rs10757274和rs10757278等7个SNP位点进行多态性分型,并对冠心病患者冠脉造影结果进行Gensini评分,分析冠心病危险等位基因对冠心病的预测及冠脉病变严重程度判断的意义。结果:冠心病组存在的危险等位基因个数(5.7±1.704)明显高于对照组的(2.37±1.173),两者差异具有统计学意义(P<0.01)。冠心病组遗传危险评分在3分以上的(9.45±3.410),明显高于≤3分的患者(P<0.05))。进一步分析遗传危险评分与冠脉病变严重程度的相关性,结果危险评分≤3分与>3分的患者Gensini积分分别为(48.33±18.573;46.20±30.813,P>0.05)。结论:遗传危险SNP数量与冠心病心肌梗死的发病显著相关。冠心病组遗传危险评分与Gensini积分不存在相关性,提示危险基因评分与冠心病的严重程度无显著相关性。更多还原

【Abstract】 Objective To discuss the seven SNP in 9p21 chromosome in patients with coronary heart disease(CHD)in Han Chinesein Kunmingregion, and the relationship betweenthe severityof CHD. Method 200 cases of CHD were analyzed by PCRSNP streamtechnologyforrs1333040, rs1333049, rs2383206, rs2383207, rs10116277, rs10757274andrs10757278 genotyping. The sense of riskallele predictionfor CHD and the severity of CHD were analyzed and determined. Result CHDgenetic riskscore was higher than 3 points(9.45 ± 3.410), significantly higher than in patients ≤ 3points(P < 0.05).Gensini risk score ≤ 3pointsand >3 pointsin patientswas(48.33 ± 18.573;46.20 ± 30.813,P > 0.05). Conclusion The number of SNPgenetic risk is significantly associatedwiththe incidence of CHD myocardial infarction. The generisk score andthe severity ofcoronary heart diseasehas no significantcorrelation.更多还原