【摘要】 目的研究在取卵当日从发育不同步且未行穿刺抽吸的大卵泡中是否获得卵母细胞对IVF/ICSI-ET的临床结局的影响。方法回顾性分析卵泡发育不同步且未行大卵泡穿刺抽吸的146个IVF/ICSI-ET周期的临床资料。根据取卵日大卵泡中是否获得卵母细胞分为两组:未获卵组(A组,72个周期)和获卵组(B组,74个周期)。比较两组卵母细胞成熟率、2PN正常受精率、2PN卵裂率、优质胚胎率、胚胎种植率及临床妊娠率等的差别。结果 A、B两组的基本情况如女方年龄、不育年限、促性腺激素(Gn)总量、Gn天数、基础和HCG日的FSH、LH、E2、孕酮(P)水平,移植日子宫内膜厚度等,均无显著性差异(P>0.05)。A组的卵母细胞成熟率(91.21%)及2PN卵裂率(98.74%)均高于B组(86.46%和96.54%)(P<0.05)。两组的平均获卵数、平均移植胚胎数、2PN正常受精率、2PN卵裂率、优质胚胎率、胚胎种植率及临床妊娠率均无显著性差异(P>0.05)。结论在控制性促排卵(COH)过程中如出现卵泡发育不同步且未行大卵泡穿刺的患者,可调整Gn用量来调节卵泡发育。在取卵日是否从大卵泡中穿刺获得卵母细胞并不影响临床妊娠结局。更多还原

【Abstract】 Objective:To investigate if oocytes were retrieved from the dominant follicle without experienced puncture would affect the clinical outcome in IVF-ET cycle.Methods:The data of 146 patients with desynchronized follicle development and without experienced follicular puncture in IVF-ET cycle were analyzed retrospectively.The patients were divided into two groups:group A with oocyte retrieved(72cycles)and group B without oocyte retrieved(74cycles),according to whether oocytes were obtained from the dominant follicles on the day of oocyte retrieval.The rates of mature oocytes,normal fertilization,cleavage,high quality embryo,embryo implantation and clinical pregnancy were compared between the group A and group B.Results:The general condition such as female age,duration of infertility,the amount and duration of gonadotropins used,the basal levels of FSH,LH and E2,the levels of FSH,LH,E2 and progesterone on HCG day were not significantly different(P>0.05).The mature oocytes rate(91.21% vs.86.46%)and2PN cleavage rate(98.74% vs.96.54%)were significantly higher in group B than those in group A(P<0.05).The number of oocytes retrieved,number of embryos implanted,the rates of normal fertilization,cleavage,high quality embryo,embryo implantation,clinical pregnancy were not significantly different(P>0.05).Conclusions:The follicular development can be regulated by adjusting the amount of gonadotropins used for the patients with desynchronized follicle development.Whether the oocytes were retrieved from the dominant follicle without experienced puncture would not affect the clinical outcome in IVF-ET cycle.更多还原