【摘要】 目的:探讨血清C肽与2型糖尿病下肢动脉硬化的关系。方法:选取214例2型糖尿病患者,分为非下肢动脉硬化组(91例)和下肢动脉硬化组(123例)。检测患者空腹C肽(CP0),馒头餐后1 h(CP1)、2 h(CP2)、3 h(CP3)C肽,糖化血红蛋白(Hb A1c)等指标。结果 :下肢动脉硬化组的年龄、糖尿病病程、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、Hb A1c、吸烟率高于非动脉硬化组(P<0.05),高密度脂蛋白胆固醇(HDL-C)低于后者(P<0.05);两组其他指标无相关性(P>0.05)。经Logistic回归分析,空腹与餐后(1、2、3 h)C肽与下肢动脉硬化呈负相关,经其他相关因素校正后仍显著相关(OR 0.524,P=0;OR 0.440,P=0;OR 0.688,P=0;OR 0.795,P=0)。结论 :血清C肽为2型糖尿病下肢动脉硬化独立相关因子。更多还原

【Abstract】 Objective To investigate the relationship between C-peptide and artherosclerosis in lower extremity in patients with type 2 diabetes.Methods Two hundred and fourteen type 2 diabetic patients were included in this retrospective study.They were divided into two groups : type 2 diabetes with artherosclerosis in lower extremity in 123 cases and type 2 diabetes without artherosclerosis in lower extremity in 91 cases.Their medical history and the laboratory data were collected such as fasting serum C-peptide levels and postprandial serum C-peptide levels of1 hour,2 hours and 3 hours,glycated hemoglobin(Hb A1c) and so on.Results Compared with artherosclerosis group in lower extremity,the age,duration of diabetes,total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),glycated hemoglobin and smoking rate were significantly higher in type 2 diabetes without artherosclerosis in lower extremity(P < 0.05).However,the high density lipoprotein cholesterol(HDL-C) was much lower in the last group(P < 0.05).There were no significant differences in the other indicators between the two groups(P >0.05).Logistic regression analysis showed that fasting and postprandial(1 hour,2 hours and 3 hours)serum C-peptide levels were all negatively related to artherosclerosis in lower extremity(OR 0.524,P = 0; OR 0.440,P = 0;OR 0.688,P = 0; OR 0.795,P = 0).Conclusions Serum C-peptide level may be an independent associated factor with artherosclerosis in lower extremity in type 2 diabetes.更多还原