【摘要】 目的:探讨上海汉族人群中转化生长因子-β1(TGF-β1)基因多态性位点T896C与2型糖尿病的关系。方法:采用病例-对照研究设计,以经确诊的1 234例2型糖尿病患者作为病例组,选取1 272例正常健康个体作为对照组。收集研究对照血液标本5 m L,提取全基因组DNA。应用Taqman基因分型技术进行多态性检测。结果:TGF-β1基因T896C位点基因型及等位基因频率分布在病例组和对照组中比较差异均有统计学意义(基因型:P=0.000 1;等位基因:P=0.004,OR=1.18[1.05~1.33])。结论:TGF-β1基因T896C位点可能与上海汉族人群2型糖尿病具有相关性。更多还原

【Abstract】 Objective To study the association between transforming growth factor- β1(TGF-β1)polymorphism and type 2 diabetes mellitus in Han population of Shanghai. Methods In this case-control study,1 234 cases of T2 DM patients were recruited and 1 272 healthy individuals were selected as control. Five ml of blood sample was collected from each subject,from which the whole genomic DNA was extracted.The polymorphism was detected by the Taqman technology. Result Significant association was observed in TGF-β1 T896 C genotypes and alleles with T2DM(P = 0.0001 and P = 0.004, OR = 1.18 [1.05 ~ 1.33 ], respectively).Conclusion The polymorphism of T896 C in TGF-β1 gene may be associated with T2 DM in Han population from Shanghai.更多还原