【摘要】 目的:比较多次屏气与呼吸触发氢质子磁共振波谱(hydrogen 1 magnetic resonance spectroscopy,1H-MRS)对肝脏脂肪含量量化的一致性和相关性。方法 :60例受试者使用1.5 T磁共振扫描仪在肝脏Ⅶ段分别行多次屏气和呼吸触发1H-MRS采集。分别记录波谱曲线中亚甲基峰和水峰下面积,计算脂肪分数。计算两者的Pearson相关系数、Bland-Altman 95%一致性界限和一致性相关系数。结果:多次屏气和呼吸触发1H-MRS得到的平均肝脏脂肪含量分别为(8.6±8.7)%和(9.4±9.3)%,两者高度相关(r=0.973,P<0.0001;一致性相关系数为0.95)。用Bland-Altman方法 ,91.7%点都在95%一致性界限内。结论 :多次屏气与呼吸触发1H-MRS均能用于量化肝脏脂肪含量。这两种方法高度相关且一致性良好。更多还原

【Abstract】 Objective To compare the consistency and correlation of multiple breath-hold(BH) with respiratory-triggered(RT)1H-MRS for quantification of hepatic lipid content. Methods Sixty subjects were underwent RT1H-MRS of the liver(Couinaud segment VII) and BH1H-MRS at 1.5 Tesla Magnetic Resonace Imaging(MRI). The peak areas of water and methylene obtained on RT and BH1H-MRS were recorded respectively and the liver fat fraction was calculated. Pearson correlation coefficient, Bland-Altman 95% limit of agreement, and concordance correlation coefficient were calculated. Results Mean liver fat fraction measured in RT and BH1H-MRS were(8.6 ± 8.7)% and(9.4 ± 9.3)% respectively. There was a strong correlation between RT and BH1H-MRS(r = 0.973, P < 0.000 1, concordance correlation coefficient = 0.95). With the Bland-Altman method, 91.7% data points were within the 95% limits of agreement. Conclusion RT and BH1H-MRS are alternative tools for intrahepatic lipid quantification. These two methods have a strong correlation and perfect consistency.更多还原