【摘要】 目的:为早期筛查腹主动脉瘤(abdominal aortic aneurysm,AAA)以及深入研究动脉粥样硬化在AAA发病中的作用提供理论依据。方法 :对广东省人民医院2013-2014年期间30例诊断明确的AAA(病例组)与26例健康人群(对照组)做对照研究,用贝克曼AU5800和贝克曼DXC800检测两组总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、脂蛋白a(Lpa)、游离脂肪酸(NEFA)、载脂蛋白A(Apo A)、载脂蛋白B(Apo B)以及同型半胱氨酸(HCY)等指标。检测结果采用SPSS 17.0进行两独立样本均数的t检验分析。结果:病例组血清TG浓度为(1.59±0.56)mmol/L,明显高于对照组的(1.11±0.34)mmol/L(P<0.05)。病例组Apo A和HDL水平分别为(1.08±0.30)g/L和(0.95±0.30)mmol/L,明显低于对照组的(1.41±0.08)g/L和(1.35±0.10)mmol/L(P<0.05)。病例组血清HCY浓度为(21.00±6.64)μmol/L,明显高于对照组的(10.61±1.99)μmol/L(P<0.05)。两组Apo B、TC、LDL、Lpa、NEFA之间差异无统计学意义(P>0.05)。结论:AAA患者血清TG和HCY水平与其发病呈正相关,Apo A和HDL水平则与其发病呈负相关。更多还原

【Abstract】 Objective To evaluate the relationship between dyslipidemia and abdominal aortic aneurysm(AAA), with which as a theory base and proof we may further study about the mechanism of atherosclerosis(AS)leading to AAA. Methods Thirty abdominal aortic aneurysm patients in Guangdong General Hospital from 2013 to2014 were enrolled into the experimental group and 26 healthy people into the control group. The serum levels of total cholesterol(TC), triglyceride(TG), high density lipoprotein(HDL), low density lipoprotein(LDL),lipoprotein a(Lpa), nonestesterified fatty acid(NEFA), homocysteine(HCY), apolipoprotein A(Apo A) and apolipoprotein B(Apo B)were tested in the study. The statistical significance of the difference of them was examined by the independent two-sample t-test. Result The serum TG and HCY level in the experimental group weresignificantly higher than those in the control group(P < 0.05). The serum Apo A and HDL level in the experimental group were significantly lower than those in the control group(P < 0.05). The serum levels of TC, LDL, Lpa,NEFA and Apo B had no significant difference in both groups(P > 0.05). Conclusion The serum levels of TG and HCY are increased and the levels of Apo A and HDL are decreased in patients with AAA.更多还原