【摘要】 目的调查深圳市活禽市场活禽经营人员H7N9禽流感病毒抗体水平,探讨感染危险因素。方法在对活禽市场活禽经营人员问卷调查的基础上,采集血样,用血凝抑制试验检测H7N9禽流感病毒抗体,采用单因素分析和多因素Logistic回归对H7N9病毒感染的危险因素进行分析。结果 250名活禽市场活禽经营中,男性141人,女性109人,年龄中位数为41岁,38人(15.2%)H7N9病毒抗体阳性(滴度≥1:160),男、女各19人。问卷调查发现,236人(94.4%)主要接触鸡,169人(67.6%)接触过鸭,120人(48.0%)接触过鹅,105人(34.1%)接触过鸽子,单因素分析显示接触鸭子、鹅和鸽子为H7N9病毒感染的高危因素,进一步多因素Logistic回归分析结果显示,接触鸭子为H7N9病毒感染的高危因素(OR=3.85,95%CI:1.44~10.35,P=0.007),活禽暴露时间、暴露方式和流感疫苗接种等因素对H7N9病毒感染的影响无显著性(P>0.05)。结论活禽市场活禽经营人员中存在着一定数量的隐性感染者,接触鸭子为H7N9病毒感染的危险因素。更多还原

【Abstract】 Objective To investigate the antibody against H7N9 avian influenza virus among poultry workers in poultry markets in Shenzhen City so as to identify the risk factors associated with its infection. Methods Subjects were recruited in poultry markets,and questionnaire survey was conducted.Blood samples were taken for detecting the antibody against novel influenza A H7N9 virus by using hemagglutination-inhibition test.Univariate analysis and multivariate analysis were employed to identify the risk factors related to H7N9 infection. Results A total of 250 subjects were recruited for serological survey with age median of 41 years,including 141 males and 109 females.38(15.2%)poultry workers were found to be positive for antibody against novel influenza A H7N9virus(titer≥1:160),including 19 males and 19 females.Questionnaire survey showed that 236(94.4%)had exposure to chickens,169(67.6%)had exposure to ducks,120(48.0%)had exposure to geese and 105(34.1%)had exposure to pigeons.Univariate analysis showed that exposure to ducks,geese and pigeons was high-risk factor for H7N9 infection.Further multivariate analysis showed that only exposure to ducks was the high-risk factor for H7N9infection(OR=3.85,95%CI:1.44-10.35,P=0.007).Other factors,such as the time of exposure to poultry,the way of exposure and seasonal influenza vaccination,were not identified to affect H7N9 infection significantly(P>0.05). Conclusions The comparatively high seropositivity to novel influenza A H7N9 virus among poultry workers in poultry markets in Shenzhen suggests that there are asymptomatic patients among them.Exposure to ducks is the risk factor for H7N9 virus infection.更多还原